Progress in Neuro-Psychopharmacology and Biological Psychiatry 1985-01-01

Comparison of the effects of amphetamine and a fluorinated analogue on locomotion and exploratory activity in the mouse.

R E Dubin, R J Reiffenstein, G B Baker, R T Coutts, A Benderly

Index: Prog. Neuropsychopharmacol. Biol. Psychiatry 9(5-6) , 681-5, (1985)

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Abstract

(+)-Amphetamine (AM) and its fluorinated analogue (+)-2-amino-3-fluoro-1-phenylpropane (fluoroamphetamine, FAM) were compared with regard to their effects on locomotor and exploratory activity in mice. Both drugs caused a reduction in spontaneous exploration, but this effect was more marked with FAM than with AM at 1 h after injection. Both compounds increased locomotor activity 10 min after injection, but FAM had sedative effects after 1 h, while AM continued to be stimulatory.