Journal of Asian Natural Products Research 2014-12-01

Adlumiceine methyl ester, a new alkaloid from Fumaria vaillantii.

Milad Iranshahy, Hamideh Javidi-Shirazi, Ngoc B Pham, Ronald J Quinn, Hamid Sadeghian, Mehrdad Iranshahi

Index: J. Asian Nat. Prod. Res. 16(12) , 1148-52, (2014)

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Abstract

A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The structures of compounds were determined by 1D/2D NMR and MS data. All three compounds were tested for cytotoxic activity against PC3 and MCF7 cell lines using Alamar blue assay. The tested compounds showed no significant cytotoxic activity (IC50>50 μM) against PC3 and MCF7 cell lines.