Organic Letters 2008-06-19

A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives.

Gang Zhou, Pauline Ting, Robert Aslanian, John J Piwinski

Index: Org. Lett. 10(12) , 2517-20, (2008)

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Abstract

A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed alpha-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.