Organic & Biomolecular Chemistry 2012-10-14

One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature.

Haoyue Xiang, Xueyu Qi, Yuyuan Xie, Guangyu Xu, Chunhao Yang

Index: Org. Biomol. Chem. 10(38) , 7730-8, (2012)

Full Text: HTML

Abstract

An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities.