Tetrahedron

Models of folate coenzymes—VIII: An approach to yohimbane alkaloids via carbon-fragment transfer from N5, N10-methylenetetrahydrofolate models

HC Hiemstra, H Bieräugel, M Wijnberg, UK Pandit

Index: Hiemstra, H. C.; Bieraeugel, H.; Wijnberg, M.; Pandit, U. K. Tetrahedron, 1983 , vol. 39, # 23 p. 3981 - 3986

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Citation Number: 27

Abstract

2-Substituted 1-tosyl-3, 4, 4-trimethylimidazolidines prepared by the addition of anions to 1- tosyl-3, 4, 4-trimethyl-2-imidazolinium iodide 1, react with tryptamine in the presence of acetic acid to give 1-substituted β-carboline derivatives. The salt 1 reacts with anions of 2-[2- (1, 3-dithianyl)] benzoates 4a-c to give the corresponding imidazolidines 5a, 5b and 5c, respectively. These transfer the substituted fragment to tryptamine to give pentacyclic ...