Il Farmaco 2000-02-01

An efficient method for the synthesis of sulbactam pivoxil.

L S Changov, B K Vassileva, M N Confino, N N Agapova

Index: Il Farmaco 55(2) , 134-5, (2000)

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Abstract

Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic solvents.