N6, 9-Disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor

RD Thompson, S Secunda, JW Daly…

Index: Thompson, Robert D.; Secunda, Sherrie; Daly, John W.; Olsson, Ray A. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2877 - 2882

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Citation Number: 66

Abstract

Ns-Subatituted 9-methyladenines are potent antagonists of the activation of AI adenosine receptors. The present study asseased the effect of N8 and N-9 Substituents on the binding of adenines to the Al and & receptors, respectively, of rat brain cortex and striatum and also on the antagonism of the Az receptor mediated stimulation of the adenylate cyclase of PC12 cells by N-ethyladenosine-5'-uronamide. The potency ranking of 9-substituted adenines ...