Bioorganic & Medicinal Chemistry Letters 2007-04-01

Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.

Hao Chen, Janet L Taylor, Suzanne R Abrams

Index: Bioorg. Med. Chem. Lett. 17 , 1979-83, (2007)

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Abstract

A library of potential antifungal triazole-modified beta-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.