Bioorganic & Medicinal Chemistry 1998-06-01

Coumarin 1,4-dihydropyridine derivatives.

P Valenti, A Rampa, R Budriesi, A Bisi, A Chiarini

Index: Bioorg. Med. Chem. 6(6) , 803-10, (1998)

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Abstract

A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompanied by a decrease of the activity on myocardial and vascular parameters, but the synthesized compounds showed selective inhibiting effects on cardiac contractility and frequency.