Bioorganic & Medicinal Chemistry Letters 2004-02-09

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.

Laval Chan, Sanjoy K Das, T Jagadeeswar Reddy, Carl Poisson, Mélanie Proulx, Oswy Pereira, Marc Courchesne, Caroline Roy, Wuyi Wang, Arshad Siddiqui, Constantin G Yannopoulos, Nghe Nguyen-Ba, Denis Labrecque, Richard Bethell, Martine Hamel, Philippe Courtemanche-Asselin, Lucille L'Heureux, Maud David, Olivier Nicolas, Stéphanie Brunette, Darius Bilimoria, Jean Bédard

Index: Bioorg. Med. Chem. Lett. 14(3) , 793-6, (2004)

Full Text: HTML

Abstract

The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in Huh-7 cells.