Chemical Communications 2002-03-21

A new strategy towards the total synthesis of phenanthridone alkaloids: synthesis of (+)-2,7-dideoxypancratistatin as a model study.

Ganesh Pandey, Andiappan Murugan, Madhesan Balakrishnan

Index: Chem. Commun. (Camb.) (6) , 624-5, (2002)

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Abstract

A new strategy towards the synthesis of phenanthridone alkaloids has been reported through the synthesis of (+)-2,7-dideoxypancratistatin from D-(-)-quinic acid employing PET initiated carbocyclization of an electron rich aromatics by silylenol ether as a key step.