Tetrahedron letters

An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds

MM Majireck, JA Witek, SM Weinreb

Index: Majireck, Max M.; Witek, Jason A.; Weinreb, Steven M. Tetrahedron Letters, 2010 , vol. 51, # 27 p. 3555 - 3557

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Citation Number: 15

Abstract

A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30min, followed by a brief aqueous workup.