Sarah E Webb, Andrew L Miller
Index: Biochim. Biophys. Acta 1820(8) , 1160-8, (2012)
Full Text: HTML
In recent years, as our understanding of the various roles played by Ca2+ signaling in development and differentiation has expanded, the challenge of imaging Ca2+ dynamics within living cells, tissues, and whole animal systems has been extended to include specific signaling activity in organelles and non-membrane bound sub-cellular domains.In this review we outline how recent advances in genetics and molecular biology have contributed to improving and developing current bioluminescence-based Ca2+ imaging techniques. Reporters can now be targeted to specific cell types, or indeed organelles or domains within a particular cell.These advances have contributed to our current understanding of the specificity and heterogeneity of developmental Ca2+ signaling. The improvement in the spatial resolution that results from specifically targeting a Ca2+ reporter has helped to reveal how a ubiquitous signaling messenger like Ca2+ can regulate coincidental but different signaling events within an individual cell; a Ca2+ signaling paradox that until now has been hard to explain.Techniques used to target specific reporters via genetic means will have applications beyond those of the Ca2+ signaling field, and these will, therefore, make a significant contribution in extending our understanding of the signaling networks that regulate animal development. This article is part of a Special Issue entitled Biochemical, biophysical and genetic approaches to intracellular calcium signalling.Copyright © 2011. Published by Elsevier B.V.
Structure | Name/CAS No. | Molecular Formula | Articles |
---|---|---|---|
![]() |
Aequrin,recombinant,Solution
CAS:50934-79-7 |
Role of Ca(2+) in the rapid cooling-induced Ca(2+) release f...
2012-05-01 [J. Physiol. Sci. 62(3) , 241-50, (2012)] |
A yeast expression system for functional and pharmacological...
2012-01-01 [Malaria Journal 11 , 254, (2012)] |
In vivo analysis of the calcium signature in the plant Golgi...
2012-11-01 [Cell Calcium 52(5) , 397-404, (2012)] |
A biogenic amine and a neuropeptide act identically: tyramin...
2013-04-22 [Proc. Biol. Sci. 280(1757) , 20122943, (2013)] |
Bioluminescence inhibition assay for the detection of hydrox...
2012-09-18 [Anal. Chem. 84(18) , 7648-55, (2012)] |
Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer
Copyright © 2024 ChemSrc All Rights Reserved