Bioorganic & Medicinal Chemistry Letters 2009-01-01

1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists

Duen-Ren Hou, Safiul Alam, Ting-Chun Kuan, Mani Ramanathan, Tsung-Pang Lin, Ming-Shiu Hung

Index: Bioorg. Med. Chem. Lett. 19(3) , 1022-5, (2009)

Full Text: HTML

Abstract

Development of new 1,2,3-triazoles as effective and selective CB1 receptor antagonists (IC 50 = 11.6 ± 3.4 nM; CB2/CB1 > 1000) is reported.