Journal of Cardiac Failure 2011-01-01

Doxercalciferol, a Pro-hormone of Vitamin D, Prevents the Development of Cardiac Hypertrophy in Rats

Jun H. Choi, Qingen Ke, Soochan Bae, Ji Yoo Lee, Yu Jin Kim, Ui Kyoung Kim, Cynthia Arbeeny, Ravi Thadhani, Peter M. Kang, Jun H. Choi, Qingen Ke, Soochan Bae, Ji Yoo Lee, Yu Jin Kim, Ui Kyoung Kim, Cynthia Arbeeny, Ravi Thadhani, Peter M. Kang

Index: J. Card. Fail. 17(12) , 1051-8, (2011)

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Abstract

Background Activated vitamin D analog, paricalcitol, has been shown to attenuate the development of cardiac hypertrophy in Dahl salt sensitive (DSS) rats. To determine whether an antihypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the development of cardiac hypertrophy in DSS rats.