Structure??Based Design, Synthesis, and Antifungal Activity of New Triazole Derivatives

…, W Wang, S Wang, Y Cao, J Yao, Z Miao…

Index: Sheng, Chunquan; Che, Xiaoying; Wang, Wenya; Wang, Shengzheng; Cao, Yongbing; Yao, Jianzhong; Miao, Zhenyuan; Zhang, Wannian Chemical Biology and Drug Design, 2011 , vol. 78, # 2 p. 309 - 313

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Citation Number: 17

Abstract

A series of new antifungal triazole derivatives with phenylacetamide side chain were rational designed and synthesized on the basis of the structural information of lanosterol 14- demethylase (CYP51). In vitro antifungal activity assay indicated that several compounds showed higher activity than fluconazole. Especially, compound 8h showed excellent inhibitory activity against Candida albicans and Cryptococcus neoformans (MIC= 0.0156 ...