e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Thiadiazoles. I. Synthesis and Properties of [1, 2, 5] Thiadiazolo [3, 4-d] pyrimidines1

YF Shealy, JD Clayton…

Index: Shealy,Y.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 2154 - 2160

Full Text: HTML

Citation Number: 13

Abstract

[1, 2, 5] Thiadiazolo [3, 4d] pyrimidines have been synthesized from 4, 5-diaminopyrimidines and N-sulfinylaniline. An intermediate in this reaction has been isolated. Replacement reactions have been observed to occur readily at position 7, and reductive cleavage of the thiadiazole ring has been demonstrated. Similarities in the properties of [1, 2, 5] thiadiazolo- [3, 4d] pyrimidines and pteridines have been noted. the pteridine^.^ Schrage and ...

4,5,6-Triamino-2(1H)-pyrimidinethione Structure

4,5,6-Triamino-...

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidine-5(3H)-thione,7-amino- Structure

[1,2,5]Thiadiaz...

4,5,6-Pyrimidinetriamine,2-(methylthio)- Structure

4,5,6-Pyrimidin...

~%

3-methylsulfanyl-8-thia-2,4,7,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine Structure

3-methylsulfany...

4,5-diamino-6-mercaptopyrimidine Structure

4,5-diamino-6-m...

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidine-7(3H)-thione Structure

[1,2,5]Thiadiaz...

4,5,6-Triamno-2-Methylpyrimidine Structure

4,5,6-Triamno-2...

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidin-7-amine, 5-methyl- Structure

[1,2,5]Thiadiaz...

6-morpholin-4-ylpyrimidine-4,5-diamine Structure

6-morpholin-4-y...

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidine,7-(4-morpholinyl)- Structure

[1,2,5]Thiadiaz...

2,4,5,6-Tetraaminopyrimidine Structure

2,4,5,6-Tetraam...

~%

8-thia-2,4,7,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraene-3,5-diamine Structure

8-thia-2,4,7,9-...

N4-phenylpyrimidine-4,5,6-triamine Structure

N4-phenylpyrimi...

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidin-7-amine, N-phenyl- Structure

[1,2,5]Thiadiaz...

6-Chloro-4,5-diaminopyrimidine Structure

6-Chloro-4,5-di...

N/A Structure

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidin-7-amine, N-phenyl- Structure

[1,2,5]Thiadiaz...

6-benzylsulfanyl-pyrimidine-4,5-diamine Structure

6-benzylsulfany...

N/A Structure

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidin-7-amine, N-phenyl- Structure

[1,2,5]Thiadiaz...

N/A Structure

4,5-diamino-6-mercaptopyrimidine Structure

4,5-diamino-6-m...

~%

[1,2,5]Thiadiazolo[3,4-d]pyrimidin-7-amine, N-phenyl- Structure

[1,2,5]Thiadiaz...

4,5,6-Triaminopyrimidine Structure

4,5,6-Triaminop...

~%

[1,2,5]thiadiazolo[3,4-d]pyrimidin-7-amine Structure

[1,2,5]thiadiaz...

5,6-Diamino-2-sulfanylpyrimidin-4-ol Structure

5,6-Diamino-2-s...

~%

3-sulfanylidene-8-thia-2,4,7,9-tetrazabicyclo[4.3.0]nona-1,6-dien-5-one Structure

3-sulfanylidene...

N4,N4-dimethyl-pyrimidine-4,5,6-triamine Structure

N4,N4-dimethyl-...

~%

N,N-dimethyl-8-thia-2,4,7,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine Structure

N,N-dimethyl-8-...