ChemMedChem

Synthesis and Evaluation of 3, 4??Dihydropyrimidin??2 (1H)??ones as Sodium Iodide Symporter Inhibitors

P Lacotte, C Puente, Y Ambroise

Index: Lacotte, Pierre; Puente, Celine; Ambroise, Yves ChemMedChem, 2013 , vol. 8, # 1 p. 104 - 111

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Citation Number: 12

Abstract

Abstract The sodium iodide symporter (NIS) is responsible for the accumulation of iodide in the thyroid gland. This transport process is involved in numerous thyroid dysfunctions and is the basis for human contamination in the case of exposure to radioactive iodine species. 4- Aryl-3, 4-dihydropyrimidin-2 (1H)-ones were recently discovered by high-throughput screening as the first NIS inhibitors. Described herein are the synthesis and evaluation of ...