Improved Synthesis of Buprenorphine from Thebaine and/or Oripavine via Palladium??Catalyzed N??Demethylation/Acylation and/or Concomitant O??Demethylation

~85%

~41%

~85%

~78%

~79%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~35%

~%

~%

~%