Tetrahedron

Reaction of secondary and tertiary aliphatic halides with aromatic aldehydes mediated by chromium (II): a selective cross-coupling of alkyl and ketyl radicals

LA Wessjohann, G Schmidt, HS Schrekker

Index: Wessjohann, Ludger A.; Schmidt, Gisela; Schrekker, Henri S. Tetrahedron, 2008 , vol. 64, # 9 p. 2134 - 2142

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Citation Number: 15

Abstract

Takai–Utimoto reactions with secondary and tertiary aliphatic halides usually failed according to previous reports. Now, significant improvements could be achieved, and especially secondary aliphatic halides can be coupled to aromatic aldehydes in yields of up to> 95%. A variety of processes are competing with the desired one, and thus conditions must be adapted to the nature of the aldehyde as well as the aliphatic halide used, as the ...