Quinolin-8-ol

RTECS NUMBER :
VC4200000
CHEMICAL NAME :
8-Quinolinol
CAS REGISTRY NUMBER :
148-24-3
BEILSTEIN REFERENCE NO. :
0114512
LAST UPDATED :
199712
DATA ITEMS CITED :
47
MOLECULAR FORMULA :
C9-H7-N-O
MOLECULAR WEIGHT :
145.17
WISWESSER LINE NOTATION :
T66 BNJ JQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1210 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
83600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD20 - Lethal Dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1205 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45 gm/kg/15D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Musculoskeletal - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 gm/kg/15D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Musculoskeletal - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 gm/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - testicular tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 gm/kg/82W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7200 mg/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg/21W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5600 mg/kg/35W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34 gm/kg/84W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - uterine tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Micronucleus test
MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
2600 ug/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,101,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,101,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81590 No. of Facilities: 685 (estimated) No. of Industries: 8 No. of Occupations: 10 No. of Employees: 5733 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81590 No. of Facilities: 857 (estimated) No. of Industries: 6 No. of Occupations: 10 No. of Employees: 13728 (estimated) No. of Female Employees: 9645 (estimated)
Safety Information
[ Symbol ]: GHS07
GHS07
[ Signal Word ]: Warning
[ Hazard Statements ]: H302
[ Personal Protective Equipment ]: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]: Xn:Harmful
[ Risk Phrases ]: R22;R36/37/38;R68
[ Safety Phrases ]: S45-S36/37/39-S26
[ RIDADR ]: 2811
[ WGK Germany ]: 3
[ RTECS ]: VC4200000
[ HS Code ]: 2933499090
Synthetic RoutePrevious 1/17 Next
Diiodohydroxyquinoline
83-73-8

Diiodohydroxyqu...

~81%

Quinolin-8-ol
148-24-3

Quinolin-8-ol

Literature: Takacs, Attila; Szilagyi, Antal; Acs, Peter; Mark, Laszlo; Peixoto, Andreia F.; Pereira, Mariette M.; Kollar, Laszlo Tetrahedron, 2011 , vol. 67, # 13 p. 2402 - 2406
Diiodohydroxyquinoline
83-73-8

Diiodohydroxyqu...

~51%

Quinolin-8-ol
148-24-3

Quinolin-8-ol

5-iodoquinolin-8-ol
13207-63-1

5-iodoquinolin-...

7-iodo-8-hydroxyquinoline
7385-89-9

7-iodo-8-hydrox...

Literature: Takacs, Attila; Szilagyi, Antal; Acs, Peter; Mark, Laszlo; Peixoto, Andreia F.; Pereira, Mariette M.; Kollar, Laszlo Tetrahedron, 2011 , vol. 67, # 13 p. 2402 - 2406
quinolin-8-yl trifluoromethanesulfonate
108530-08-1

quinolin-8-yl t...

~93%

Quinolin-8-ol
148-24-3

Quinolin-8-ol

Literature: Green, Alice E.; Agouridas, Vangelis; Deniau, Eric Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7078 - 7079
Precursor & DownStream
Precursor 9 Previous 1/3 Next
Diiodohydroxyquinoline Structure CAS#:83-73-8
Diiodohydroxyqu...
quinolin-8-yl trifluoromethanesulfonate Structure CAS#:108530-08-1
quinolin-8-yl t...
leucoline Structure CAS#:91-22-5
leucoline
aminophenol Structure CAS#:95-55-6
aminophenol
DownStream 10 Previous 1/3 Next
(8-phenylmethoxyquinolin-5-yl)methanol structure CAS#:108835-25-2
(8-phenylmethox...
quinolin-8-yl trifluoromethanesulfonate structure CAS#:108530-08-1
quinolin-8-yl t...
7-[(8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]quinolin-8-ol structure CAS#:105192-47-0
7-[(8-hydroxyqu...
7-[(8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]quinolin-8-ol structure CAS#:105192-48-1
7-[(8-hydroxyqu...
Customs
[ HS Code ]: 2933499090
[ Summary ]: 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles68More Articles
Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analysed by flow cytometry.
J. Med. Microbiol. 63(Pt 12) , 1663-9, (2014)

The major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident pro...

Detail
Synthesis of a monofunctional platinum compound and its activity alone and in combination with phytochemicals in ovarian tumor models.
Anticancer Res. 34(12) , 7077-90, (2014)

Currently used platinum drugs fail to provide long-term cure for ovarian cancer mainly because of acquired drug resistance. In this study, a new monofunctional planaramineplatinum(II) complex, namely ...

Detail
An analytical quality by design (aQbD) approach for a L-asparaginase activity method.
J. Pharm. Biomed. Anal. 117 , 232-9, (2015)

L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality co...

Detail
Synonyms
8-Hydroxyquinoline
8-Oxychinolin
MFCD00006807
Oxine
oxychinolin
(8-hydroxy)quinoline
T66 BNJ JQ
Tumex
8-OQ
8-Quinol
Fennosan
Quinolin-8-ol
8-OH-quinoline
EINECS 205-711-1
8-oxyquinoline
8-Quinolinol
8-hydroxy-quinoline
8-Quinolinone
oxybenzopyridine
Quinophenol