KRAS G12C inhibitor 11
Modify Date: 2025-08-27 12:57:21
KRAS G12C inhibitor 11 structure
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Common Name | KRAS G12C inhibitor 11 | ||
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| CAS Number | 2158297-63-1 | Molecular Weight | 551.68 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H37N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRAS G12C inhibitor 11KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147[1]. |
| Name | KRAS G12C inhibitor 5 |
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| Description | KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147[1]. |
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| Related Catalog | |
| Target |
KRas G12C[1] |
| In Vitro | Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation[1]. |
| References |
[1]. John P. Fischer, et al. Kras g12c inhibitors. WO2017201161A1. |
| Molecular Formula | C32H37N7O2 |
|---|---|
| Molecular Weight | 551.68 |
| InChIKey | OBKBMFMBHWUYHS-DQEYMECFSA-N |
| SMILES | C=CC(=O)N1CCN(c2nc(OCC3CCCN3C)nc3c2CCN(c2cccc4ccccc24)C3)CC1CC#N |
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Name: Half life in in presence of GSH in phosphate buffer at 1 uM at 37 degC by LC-MS/M ana...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4612366
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Name: Apparent permeability in pig LLC-PK1 cells
Source: ChEMBL
Target: N/A
External Id: CHEMBL4612369
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Name: Hepatic extraction ratio in human liver microsomes
Source: ChEMBL
Target: N/A
External Id: CHEMBL4612357
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Name: Hepatic extraction ratio in human hepatocytes at 10 uM incubated for 2 hrs by LC-MS a...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4612356
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Name: Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK p...
Source: ChEMBL
Target: GTPase KRas
External Id: CHEMBL4612347
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