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Profiling and genetic control of the murine immunoglobulin G glycome
10.1038/s41589-018-0034-3 2018-04-09 Immunoglobulin G (IgG) glycosylation is essential for function of the immune system, but the genetic and environmental factors that underlie its inter-individual variability are not well defined. The Collaborative Cross (CC) genetic resource harnesses over 90... |
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A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
10.1038/s41589-018-0035-2 2018-04-09 Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the crypt, that express leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5). The Frizzled (FZD) 7 receptor (FZD7) is e... |
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Ligand-receptor co-evolution shaped the jasmonate pathway in land plants
10.1038/s41589-018-0033-4 2018-04-09 The phytohormone jasmonoyl-isoleucine (JA-Ile) regulates defense, growth and developmental responses in vascular plants. Bryophytes have conserved sequences for all JA-Ile signaling pathway components but lack JA-Ile. We show that, in spite of 450 million yea... |
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The cyanobacterial ornithine–ammonia cycle involves an arginine dihydrolase
10.1038/s41589-018-0038-z 2018-04-09 Living organisms have evolved mechanisms for adjusting their metabolism to adapt to environmental nutrient availability. Terrestrial animals utilize the ornithine–urea cycle to dispose of excess nitrogen derived from dietary protein. Here, we identified an ac... |
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Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway
10.1038/s41589-018-0036-1 2018-04-09 The N-end rule pathway senses the N-terminal destabilizing residues of degradation substrates for the ubiquitin-proteasome system, whose integrity shields against various human syndromes including cancer and cardiovascular diseases. GID4, a subunit of the ubi... |
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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
10.1038/s41589-018-0031-6 2018-04-02 Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO2 is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in engineered cancer ... |
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Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function
10.1038/s41589-018-0032-5 2018-04-02 Single-fluorescent-molecule imaging tracking (SMT) is becoming an important tool to study living cells. However, photobleaching and photoblinking (hereafter referred to as photobleaching/photoblinking) of the probe molecules strongly hamper SMT studies of liv... |
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The structural organization of substrate loading in iterative polyketide synthases
10.1038/s41589-018-0026-3 2018-04-02 Polyketide synthases (PKSs) are microbial multienzymes for the biosynthesis of biologically potent secondary metabolites. Polyketide production is initiated by the loading of a starter unit onto an integral acyl carrier protein (ACP) and its subsequent transf... |
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Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes
10.1038/s41589-018-0040-5 2018-04-02 Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes, Published online: 02 April 2018; doi:10.1038/s... |
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The dTAG system for immediate and target-specific protein degradation
10.1038/s41589-018-0021-8 2018-03-26 Dissection of complex biological systems requires target-specific control of the function or abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent complexity, and irreversibility. Most limiting is the requisite delay b... |