Latest Articles of ACS Biomaterials Science & Engineering


Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up 10.1021/acsbiomaterials.7b00747 2018-04-16 Decellularized extracellular matrixes (dECM) derived from mesenchymal stem cell (MSC) cultures have recently emerged as cell culture substrates that improve the proliferation, differentiation, and maintenance of MSC phenotype during ex vivo expansion. These b...
Recombinant Spider Silk Hydrogels for Sustained Release of Biologicals 10.1021/acsbiomaterials.8b00382 2018-04-16 Therapeutic biologics (i.e., proteins) have been widely recognized for the treatment, prevention, and cure of a variety of human diseases and syndromes. However, design of novel protein-delivery systems to achieve a nontoxic, constant, and efficient delivery ...
Targeting Early Apoptosis in Acute Ischemic Stroke with a Small-Molecule Probe 10.1021/acsbiomaterials.8b00213 2018-04-13 Inhibiting apoptotic cells helps ameliorate ischemic injury. Actually, only the apoptotic cells in early stage could be rescued. Molecular imaging of the early apoptosis would make sense in ischemic stroke; however, few of apoptosis molecular probes could spe...
Nanohydroxyapatite/Graphene Nanoribbons Nanocomposites Induce in Vitro Osteogenesis and Promote in Vivo Bone Neoformation 10.1021/acsbiomaterials.7b01032 2018-04-12 Nanomaterials based on graphene oxide nanoribbons (GNR) and nanohydroxyapatite (nHAp) serve as attractive materials for bone tissue engineering. Herein, we evaluated the potential of nHAp/GNR toward in vitro analysis of specific genes related to osteogenesis ...
Consecutive Spray Drying to Produce Coated Dry Powder Vaccines Suitable for Oral Administration 10.1021/acsbiomaterials.8b00117 2018-04-10 Current global vaccination programs are challenged by costs associated with vaccine cold chain storage and administration. A solid, thermally stable oral dosage form for vaccines would alleviate these costs but is difficult to produce due to general vaccine i...
Higher Biostability of rh-aFGF-Carbomer 940 Hydrogel and Its Effect on Wound Healing in a Diabetic Rat Model 10.1021/acsbiomaterials.8b00011 2018-04-10 Hydrogels are excellent drug delivery carriers with excellent ductility. Here, we report the design of a higher biostability of a recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer hydrogel formulation. To verify the optimality of this formu...
Fabrication of High Aspect Ratio Millimeter-Tall Free-Standing Carbon Nanotube-Based Microelectrode Arrays 10.1021/acsbiomaterials.8b00038 2018-04-09 Microelectrode arrays of carbon nanotube (CNT)/carbon composite posts with high aspect ratio and millimeter-length were fabricated using carbon-nanotube-templated microfabrication with a sacrificial “hedge”. The high aspect ratio, mechanical robustness, and e...
Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy 10.1021/acsbiomaterials.8b00218 2018-04-06 Systemic administration of mesoporous silica nanoparticles (MSNs) in biomedical applications has recently been questioned because of poor degradability, which is necessary for the successful development of new drug-delivery systems. Herein, we report the deve...
Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth 10.1021/acsbiomaterials.8b00326 2018-04-05 Regardless of the intervention for peripheral nerve repair, slow rates of axonal regeneration often result in poor clinical outcomes. Thus, using new materials such as biologically inspired, biocompatible, organic rosette nanotubes (RNTs) could provide a tail...
Magnetically Assisted Electrodeposition of Aligned Collagen Coatings 10.1021/acsbiomaterials.7b01038 2018-04-04 Well-aligned collagen nanofibers are crucial in engineering bioinspired regenerative strategies, such as bone, muscle and cornea. However, keeping the natural bioactive of collagen and controlling its orientation in a coating still remain a challenge. Here we...

Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up

10.1021/acsbiomaterials.7b00747

2018-04-16

Decellularized extracellular matrixes (dECM) derived from mesenchymal stem cell (MSC) cultures have recently emerged as cell culture substrates that improve the proliferation, differentiation, and maintenance of MSC phenotype during ex vivo expansion. These b...

Recombinant Spider Silk Hydrogels for Sustained Release of Biologicals

10.1021/acsbiomaterials.8b00382

2018-04-16

Therapeutic biologics (i.e., proteins) have been widely recognized for the treatment, prevention, and cure of a variety of human diseases and syndromes. However, design of novel protein-delivery systems to achieve a nontoxic, constant, and efficient delivery ...

Targeting Early Apoptosis in Acute Ischemic Stroke with a Small-Molecule Probe

10.1021/acsbiomaterials.8b00213

2018-04-13

Inhibiting apoptotic cells helps ameliorate ischemic injury. Actually, only the apoptotic cells in early stage could be rescued. Molecular imaging of the early apoptosis would make sense in ischemic stroke; however, few of apoptosis molecular probes could spe...

Nanohydroxyapatite/Graphene Nanoribbons Nanocomposites Induce in Vitro Osteogenesis and Promote in Vivo Bone Neoformation

10.1021/acsbiomaterials.7b01032

2018-04-12

Nanomaterials based on graphene oxide nanoribbons (GNR) and nanohydroxyapatite (nHAp) serve as attractive materials for bone tissue engineering. Herein, we evaluated the potential of nHAp/GNR toward in vitro analysis of specific genes related to osteogenesis ...

Consecutive Spray Drying to Produce Coated Dry Powder Vaccines Suitable for Oral Administration

10.1021/acsbiomaterials.8b00117

2018-04-10

Current global vaccination programs are challenged by costs associated with vaccine cold chain storage and administration. A solid, thermally stable oral dosage form for vaccines would alleviate these costs but is difficult to produce due to general vaccine i...

Higher Biostability of rh-aFGF-Carbomer 940 Hydrogel and Its Effect on Wound Healing in a Diabetic Rat Model

10.1021/acsbiomaterials.8b00011

2018-04-10

Hydrogels are excellent drug delivery carriers with excellent ductility. Here, we report the design of a higher biostability of a recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer hydrogel formulation. To verify the optimality of this formu...

Fabrication of High Aspect Ratio Millimeter-Tall Free-Standing Carbon Nanotube-Based Microelectrode Arrays

10.1021/acsbiomaterials.8b00038

2018-04-09

Microelectrode arrays of carbon nanotube (CNT)/carbon composite posts with high aspect ratio and millimeter-length were fabricated using carbon-nanotube-templated microfabrication with a sacrificial “hedge”. The high aspect ratio, mechanical robustness, and e...

Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy

10.1021/acsbiomaterials.8b00218

2018-04-06

Systemic administration of mesoporous silica nanoparticles (MSNs) in biomedical applications has recently been questioned because of poor degradability, which is necessary for the successful development of new drug-delivery systems. Herein, we report the deve...

Bioactive Organic Rosette Nanotubes Support Sensory Neurite Outgrowth

10.1021/acsbiomaterials.8b00326

2018-04-05

Regardless of the intervention for peripheral nerve repair, slow rates of axonal regeneration often result in poor clinical outcomes. Thus, using new materials such as biologically inspired, biocompatible, organic rosette nanotubes (RNTs) could provide a tail...

Magnetically Assisted Electrodeposition of Aligned Collagen Coatings

10.1021/acsbiomaterials.7b01038

2018-04-04

Well-aligned collagen nanofibers are crucial in engineering bioinspired regenerative strategies, such as bone, muscle and cornea. However, keeping the natural bioactive of collagen and controlling its orientation in a coating still remain a challenge. Here we...