Latest Articles of Mass Spectrometry Reviews


Cross‐linked peptide identification: A computational forest of algorithms 10.1002/mas.21559 2018-03-12 Chemical cross‐linking analyzed by mass spectrometry (XL‐MS) has become an important tool in unravelling protein structure, dynamics, and complex formation. Because the analysis of cross‐linked proteins with mass spectrometry results in specific computational...
Negative ion laser desorption/ionization time‐of‐flight mass spectrometric analysis of small molecules by using nanostructured substrate as matrices 10.1002/mas.21558 2018-03-06 Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) is an excellent analytical technique for rapid and sensitive analysis of macromolecules such as polymers and proteins. However, the main drawback of MALDI‐TOF MS is it...
Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases 10.1002/mas.21562 2018-02-27 In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply, researchers are now primed to uncover key metabolites and their associations with diseases...
Radical solutions: Principles and application of electron‐based dissociation in mass spectrometry‐based analysis of protein structure 10.1002/mas.21560 2018-02-09 In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have emerged as two of the most useful methods in mass spectrometry‐based protein analysis, evidenced by a considerable and growing body of literature. In large part, the interes...
Mass spectrometry for protein sialoglycosylation 10.1002/mas.21555 2017-12-11 Sialic acids are a family of structurally unique and negatively charged nine-carbon sugars, normally found at the terminal positions of glycan chains on glycoproteins and glycolipids. The glycosylation of proteins is a universal post-translational modificatio...
Mass spectrometry of aerosol particle analogues in molecular beam experiments 10.1002/mas.21554 2017-11-27 Nanometer-size particles such as ultrafine aerosol particles, ice nanoparticles, water nanodroplets, etc, play an important, however, not yet fully understood role in the atmospheric chemistry and physics. These species are often composed of water with admixt...
Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders 10.1002/mas.21553 2017-11-12 Metabolomics seeks to take a “snapshot” in a time of the levels, activities, regulation and interactions of all small molecule metabolites in response to a biological system with genetic or environmental changes. The emerging development in mass spectrometry ...
Analysis of the plasma proteome using iTRAQ and TMT-based Isobaric labeling 10.1002/mas.21550 2017-11-09 Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) reagents, has been employed in a wide range of different clinically orientated se...
A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation 10.1002/mas.21551 2017-11-09 The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization-based MS and MS/MS spectra in order to identify small-mole...
Ion traps in modern mass spectrometry 10.1002/mas.21549 2017-10-30 This review is devoted to trapping mass spectrometry wherein ions are confined by electromagnetic fields for prolonged periods of time within limited volume, with mass measurement taking place within the same volume. Three major types of trapping mass spectro...

Cross‐linked peptide identification: A computational forest of algorithms

10.1002/mas.21559

2018-03-12

Chemical cross‐linking analyzed by mass spectrometry (XL‐MS) has become an important tool in unravelling protein structure, dynamics, and complex formation. Because the analysis of cross‐linked proteins with mass spectrometry results in specific computational...

Negative ion laser desorption/ionization time‐of‐flight mass spectrometric analysis of small molecules by using nanostructured substrate as matrices

10.1002/mas.21558

2018-03-06

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) is an excellent analytical technique for rapid and sensitive analysis of macromolecules such as polymers and proteins. However, the main drawback of MALDI‐TOF MS is it...

Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases

10.1002/mas.21562

2018-02-27

In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply, researchers are now primed to uncover key metabolites and their associations with diseases...

Radical solutions: Principles and application of electron‐based dissociation in mass spectrometry‐based analysis of protein structure

10.1002/mas.21560

2018-02-09

In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have emerged as two of the most useful methods in mass spectrometry‐based protein analysis, evidenced by a considerable and growing body of literature. In large part, the interes...

Mass spectrometry for protein sialoglycosylation

10.1002/mas.21555

2017-12-11

Sialic acids are a family of structurally unique and negatively charged nine-carbon sugars, normally found at the terminal positions of glycan chains on glycoproteins and glycolipids. The glycosylation of proteins is a universal post-translational modificatio...

Mass spectrometry of aerosol particle analogues in molecular beam experiments

10.1002/mas.21554

2017-11-27

Nanometer-size particles such as ultrafine aerosol particles, ice nanoparticles, water nanodroplets, etc, play an important, however, not yet fully understood role in the atmospheric chemistry and physics. These species are often composed of water with admixt...

Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders

10.1002/mas.21553

2017-11-12

Metabolomics seeks to take a “snapshot” in a time of the levels, activities, regulation and interactions of all small molecule metabolites in response to a biological system with genetic or environmental changes. The emerging development in mass spectrometry ...

Analysis of the plasma proteome using iTRAQ and TMT-based Isobaric labeling

10.1002/mas.21550

2017-11-09

Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) reagents, has been employed in a wide range of different clinically orientated se...

A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation

10.1002/mas.21551

2017-11-09

The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization-based MS and MS/MS spectra in order to identify small-mole...

Ion traps in modern mass spectrometry

10.1002/mas.21549

2017-10-30

This review is devoted to trapping mass spectrometry wherein ions are confined by electromagnetic fields for prolonged periods of time within limited volume, with mass measurement taking place within the same volume. Three major types of trapping mass spectro...