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Three-dimensional multiscale fiber matrices: development and characterization for increased HepG2 functional maintenance for bio-artificial liver application
10.1039/C7BM00963A 2018-01-02 The development of a cell-growth substrate that provides a nature-like microenvironment, promotes cell adhesion, and maintains the cells’ functional activities is a research focus in the field of tissue engineering. In the present study, three-dimensional mic... |
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The uptake, retention and clearance of drug-loaded dendrimer nanoparticles in astrocytes – electrophysiological quantification
10.1039/C7BM00886D 2017-12-27 Nanoparticle-based drug delivery systems may impose risks to patients due to potential toxicity associated with a lack of clearance from cells or prolonged carrier-cell retention. This work evaluates vesicular cell uptake, retention and the possible transfer ... |
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Enhancement of BMP-2-mediated angiogenesis and osteogenesis by 2-N,6-O-sulfated chitosan in bone regeneration
10.1039/C7BM01006K 2017-12-27 Sulfated polysaccharides are attractive semi-synthesized materials that can be used as a mimic of heparan sulfate to modulate the protein activity and other physiological processes. In this study, we employed sulfated chitosan to enhance the angiogenic capaci... |
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Gd3+-Doped MoSe2 nanosheets used as a theranostic agent for bimodal imaging and highly efficient photothermal cancer therapy
10.1039/C7BM00894E 2017-12-22 Recently, two dimensional transition metal dichalcogenides (TMDCs) being used as nanomedicine have aroused great interest because of their unique photothermal properties. A simple liquid-phase method was used to prepare gadolinium (Gd3+)-doped molybdenum sele... |
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Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances
10.1039/C7BM00999B 2017-12-22 Nanotechnology has introduced new techniques and phototherapy approaches to fabricate and utilize nanoparticles for cancer therapy. These phototherapy approaches, such as photothermal therapy (PTT) and photodynamic therapy (PDT), hold great promise to overcom... |
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Modulating inflammation in a cutaneous chronic wound model by IL-10 released from collagen–silica nanocomposites via gene delivery
10.1039/C7BM01024A 2017-12-22 Cutaneous chronic wounds remain a major clinical challenge which requires the development of novel wound dressings. Previously, we showed that collagen–silica nanocomposites consisting of polyethyleneimine (PEI)-DNA complexes associated with silica nanopartic... |
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Enhanced wound healing in diabetic rats by nanofibrous scaffolds mimicking the basketweave pattern of collagen fibrils in native skin
10.1039/C7BM00545H 2017-12-21 Nanofibrous scaffolds that offer proper microenvironmental cues to promote the healing process are highly desirable for patients with chronic wounds. Although studies have shown that fiber organization regulates cell behaviors in vitro, little is known about ... |
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Catechol oxidation: considerations in the design of wet adhesive materials
10.1039/C7BM00884H 2017-12-21 Catechols are found as functional groups in Nature as the 3,4-dihydroxy isomer, generally with electron donating substituents and as the 2,3-dihydroxy isomer, with an electron withdrawing substituent. Adhesive properties of catechol materials rely on the vici... |
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Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair
10.1039/C7BM00974G 2017-12-18 Severe spinal cord injury (SCI) induces massive proliferation of spinal cord neural stem cells (NSCs), which are considered a promising cell source for therapeutic neural repair. However, most injury-activated spinal cord NSCs differentiate into astrocytes, r... |
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Recent advancements in biocompatible inorganic nanoparticles towards biomedical applications
10.1039/C7BM01020F 2017-12-14 Due to their intrinsic physical properties potentially useful for imaging and therapy as well as their highly engineerable surface, biocompatible inorganic nanoparticles offer novel platforms to develop advanced diagnostic and therapeutic agents for improved ... |