Latest Articles of Biomaterials Science


pH-Triggered nanostructural transformations in antimicrobial peptide/oleic acid self-assemblies 10.1039/C7BM00929A 2018-01-15 The delivery of poorly water-soluble antimicrobial peptides (AMPs) that are sensitive to degradation is a major challenge in the pharmaceutical field. In this study, we design and characterize a pH-sensitive nanocarrier with the potential for delivery of AMPs...
Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration 10.1039/C7BM01060E 2018-01-12 Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have g...
Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy 10.1039/C7BM01053B 2018-01-11 The nonspecific biodistribution of cytotoxic drugs and associated adverse effects greatly limit the efficacy and patient compliance of chemotherapy. To address this, we employed a photoswitchable microtubule inhibitor (Azo-CA4) that was physically loaded in c...
Enhanced bone defect repairing effects in glucocorticoid-induced osteonecrosis of the femoral head using a porous nano-lithium-hydroxyapatite/gelatin microsphere/erythropoietin composite scaffold 10.1039/C7BM00975E 2018-01-10 Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common debilitating disease that occurs in young and middle-aged adults. To treat early GIONFH, core decompression and bone graft are regarded as effective measures. However, the ideal bon...
A silencing-mediated enhancement of osteogenic differentiation by supramolecular ternary siRNA polyplexes comprising biocleavable cationic polyrotaxanes and anionic fusogenic peptides 10.1039/C7BM01100H 2018-01-09 Gene silencing of noggin by small interfering RNA (siRNA) is a promising approach for the treatment of bone defects, because noggin deactivates bone morphogenetic protein-2 (BMP-2) and suppresses osteogenic differentiation. Here, we demonstrated the silencing...
A flexible polyaniline-based bioelectronic patch 10.1039/C7BM00880E 2018-01-09 Bioelectronic materials based on conjugated polymers are being developed in the hope to interface with electroresponsive tissues. We have recently demonstrated that a polyaniline chitosan patch can efficiently electro-couple with cardiac tissue modulating its...
Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems 10.1039/C7BM01056G 2018-01-09 The use of neural stem cells (NSCs) in cell therapy has become a powerful tool used for the treatment of central nervous system diseases, including traumatic brain and spinal cord injuries. However, a significant drawback is related to the limited viability a...
Design of biomimetic substrates for long-term maintenance of alveolar epithelial cells 10.1039/C7BM00647K 2018-01-04 There is a need to establish in vitro lung alveolar epithelial culture models to better understand the fundamental biological mechanisms that drive lung diseases. While primary alveolar epithelial cells (AEC) are a useful option to study mature lung biology, ...
Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway 10.1039/C7BM01044C 2018-01-03 Both the topographic surface and chemical composition modification can enhance rapid osteogenic differentiation and bone formation. Till now, the synergetic effects of topography and chemistry cues guiding biological responses have been rarely reported. Herei...
A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model 10.1039/C7BM01088E 2018-01-02 A glioblastoma is a common primary brain tumor that expresses microRNA-21 (miR-21), which inhibits the expression of pro-apoptotic genes such as phosphatase and tensin homologue (PTEN) and programmed cell death 4 (PDCD4). Therefore, an antisense-oligonucleoti...

pH-Triggered nanostructural transformations in antimicrobial peptide/oleic acid self-assemblies

10.1039/C7BM00929A

2018-01-15

The delivery of poorly water-soluble antimicrobial peptides (AMPs) that are sensitive to degradation is a major challenge in the pharmaceutical field. In this study, we design and characterize a pH-sensitive nanocarrier with the potential for delivery of AMPs...

Mussel-inspired graphene oxide nanosheet-enwrapped Ti scaffolds with drug-encapsulated gelatin microspheres for bone regeneration

10.1039/C7BM01060E

2018-01-12

Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have g...

Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy

10.1039/C7BM01053B

2018-01-11

The nonspecific biodistribution of cytotoxic drugs and associated adverse effects greatly limit the efficacy and patient compliance of chemotherapy. To address this, we employed a photoswitchable microtubule inhibitor (Azo-CA4) that was physically loaded in c...

Enhanced bone defect repairing effects in glucocorticoid-induced osteonecrosis of the femoral head using a porous nano-lithium-hydroxyapatite/gelatin microsphere/erythropoietin composite scaffold

10.1039/C7BM00975E

2018-01-10

Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common debilitating disease that occurs in young and middle-aged adults. To treat early GIONFH, core decompression and bone graft are regarded as effective measures. However, the ideal bon...

A silencing-mediated enhancement of osteogenic differentiation by supramolecular ternary siRNA polyplexes comprising biocleavable cationic polyrotaxanes and anionic fusogenic peptides

10.1039/C7BM01100H

2018-01-09

Gene silencing of noggin by small interfering RNA (siRNA) is a promising approach for the treatment of bone defects, because noggin deactivates bone morphogenetic protein-2 (BMP-2) and suppresses osteogenic differentiation. Here, we demonstrated the silencing...

A flexible polyaniline-based bioelectronic patch

10.1039/C7BM00880E

2018-01-09

Bioelectronic materials based on conjugated polymers are being developed in the hope to interface with electroresponsive tissues. We have recently demonstrated that a polyaniline chitosan patch can efficiently electro-couple with cardiac tissue modulating its...

Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems

10.1039/C7BM01056G

2018-01-09

The use of neural stem cells (NSCs) in cell therapy has become a powerful tool used for the treatment of central nervous system diseases, including traumatic brain and spinal cord injuries. However, a significant drawback is related to the limited viability a...

Design of biomimetic substrates for long-term maintenance of alveolar epithelial cells

10.1039/C7BM00647K

2018-01-04

There is a need to establish in vitro lung alveolar epithelial culture models to better understand the fundamental biological mechanisms that drive lung diseases. While primary alveolar epithelial cells (AEC) are a useful option to study mature lung biology, ...

Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway

10.1039/C7BM01044C

2018-01-03

Both the topographic surface and chemical composition modification can enhance rapid osteogenic differentiation and bone formation. Till now, the synergetic effects of topography and chemistry cues guiding biological responses have been rarely reported. Herei...

A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model

10.1039/C7BM01088E

2018-01-02

A glioblastoma is a common primary brain tumor that expresses microRNA-21 (miR-21), which inhibits the expression of pro-apoptotic genes such as phosphatase and tensin homologue (PTEN) and programmed cell death 4 (PDCD4). Therefore, an antisense-oligonucleoti...