Latest Articles of Acta Biomaterialia


Customizing Poly(lactic-co-glycolic acid) Particles for Biomedical Applications 10.1016/j.actbio.2018.04.006 2018-04-11 Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegrad...
Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes 10.1016/j.actbio.2018.04.008 2018-04-09 Mechanism underlying the diabetes-induced poor osteointegration of implants remains elusive, making it a challenge to develop corresponding solutions. Here, we studied the role of angiogenesis in the diabetes-induced poor bone repair at the bone-implant inter...
Liposome-chaperoned cell-free synthesis for the design of proteoliposomes: Implications for therapeutic delivery 10.1016/j.actbio.2018.03.043 2018-04-04 Cell-free (CF) protein synthesis has emerged as a powerful technique platform for efficient protein production in vitro. Liposomes have been widely studied as therapeutic carriers due to their biocompatibility, biodegradability, low toxicity, flexible surface...
Oligoaniline-based Conductive Biomaterials for Tissue Engineering 10.1016/j.actbio.2018.03.042 2018-04-04 The science and engineering of biomaterials have improved the human life expectancy. Tissue engineering is one of the nascent strategies with an aim to fulfill this target. Tissue engineering scaffolds are one of the most significant aspects of the recent tis...
Exploiting natural polysaccharides to enhance in vitro bio-constructs of primary neurons and progenitor cells 10.1016/j.actbio.2018.03.041 2018-04-03 Current strategies in Central Nervous System (CNS) repair focus on the engineering of artificial scaffolds for guiding and promoting neuronal tissue regrowth. Ideally, one should combine such synthetic structures with stem cell therapies, encapsulating progen...
Effects of Sucrose Ester Structures on Liposome-Mediated Gene Delivery 10.1016/j.actbio.2018.03.031 2018-03-30 Sucrose esters (SEs) have great potential applications in gene delivery because of their low toxicity, excellent biocompatibility, and biodegradability. By using tripeptide-based lipid (CDO) as a model lipid and SEs as helper lipids, a series of liposomes wer...
Porous calcium phosphate glass microspheres for orthobiologic applications 10.1016/j.actbio.2018.03.040 2018-03-29 Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for production of novel porou...
3D-Printing Porosity: A New Approach to Creating Elevated Porosity Materials and Structures 10.1016/j.actbio.2018.03.039 2018-03-27 We introduce a new process that enables the ability to 3D-print high porosity materials and structures by combining the newly introduced 3D-Painting process with traditional salt-leaching. The synthesis and resulting properties of three 3D-printable inks comp...
Impact of Nitinol Stent Surface Processing on In-vivo Nickel Release and Biological Response 10.1016/j.actbio.2018.03.036 2018-03-27 Although nitinol is used widely in percutaneous cardiovascular interventions, a causal relationship between nickel released from implanted cardiovascular devices and adverse systemic or local biological responses has not been established. The objective of thi...
Adhesive gland transcriptomics uncovers a diversity of genes involved in glue formation in marine tube-building polychaetes 10.1016/j.actbio.2018.03.037 2018-03-27 Tube-building sabellariid polychaetes are hermatypic organisms capable of forming vast reefs in highly turbulent marine habitats. Sabellariid worms assemble their tube by gluing together siliceous and calcareous clastic particles using a polyelectrolytic bioc...

Customizing Poly(lactic-co-glycolic acid) Particles for Biomedical Applications

10.1016/j.actbio.2018.04.006

2018-04-11

Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegrad...

Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes

10.1016/j.actbio.2018.04.008

2018-04-09

Mechanism underlying the diabetes-induced poor osteointegration of implants remains elusive, making it a challenge to develop corresponding solutions. Here, we studied the role of angiogenesis in the diabetes-induced poor bone repair at the bone-implant inter...

Liposome-chaperoned cell-free synthesis for the design of proteoliposomes: Implications for therapeutic delivery

10.1016/j.actbio.2018.03.043

2018-04-04

Cell-free (CF) protein synthesis has emerged as a powerful technique platform for efficient protein production in vitro. Liposomes have been widely studied as therapeutic carriers due to their biocompatibility, biodegradability, low toxicity, flexible surface...

Oligoaniline-based Conductive Biomaterials for Tissue Engineering

10.1016/j.actbio.2018.03.042

2018-04-04

The science and engineering of biomaterials have improved the human life expectancy. Tissue engineering is one of the nascent strategies with an aim to fulfill this target. Tissue engineering scaffolds are one of the most significant aspects of the recent tis...

Exploiting natural polysaccharides to enhance in vitro bio-constructs of primary neurons and progenitor cells

10.1016/j.actbio.2018.03.041

2018-04-03

Current strategies in Central Nervous System (CNS) repair focus on the engineering of artificial scaffolds for guiding and promoting neuronal tissue regrowth. Ideally, one should combine such synthetic structures with stem cell therapies, encapsulating progen...

Effects of Sucrose Ester Structures on Liposome-Mediated Gene Delivery

10.1016/j.actbio.2018.03.031

2018-03-30

Sucrose esters (SEs) have great potential applications in gene delivery because of their low toxicity, excellent biocompatibility, and biodegradability. By using tripeptide-based lipid (CDO) as a model lipid and SEs as helper lipids, a series of liposomes wer...

Porous calcium phosphate glass microspheres for orthobiologic applications

10.1016/j.actbio.2018.03.040

2018-03-29

Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for production of novel porou...

3D-Printing Porosity: A New Approach to Creating Elevated Porosity Materials and Structures

10.1016/j.actbio.2018.03.039

2018-03-27

We introduce a new process that enables the ability to 3D-print high porosity materials and structures by combining the newly introduced 3D-Painting process with traditional salt-leaching. The synthesis and resulting properties of three 3D-printable inks comp...

Impact of Nitinol Stent Surface Processing on In-vivo Nickel Release and Biological Response

10.1016/j.actbio.2018.03.036

2018-03-27

Although nitinol is used widely in percutaneous cardiovascular interventions, a causal relationship between nickel released from implanted cardiovascular devices and adverse systemic or local biological responses has not been established. The objective of thi...

Adhesive gland transcriptomics uncovers a diversity of genes involved in glue formation in marine tube-building polychaetes

10.1016/j.actbio.2018.03.037

2018-03-27

Tube-building sabellariid polychaetes are hermatypic organisms capable of forming vast reefs in highly turbulent marine habitats. Sabellariid worms assemble their tube by gluing together siliceous and calcareous clastic particles using a polyelectrolytic bioc...