Latest Articles of Chemistry and Physics of Lipids


Improved Quantitative Fatty Acid Values with Correction of T2 Relaxation Time in Terminal Methyl Group: In Vivo Proton Magnetic Resonance Spectroscopy at Ultra High Field in Hepatic Steatosis 10.1016/j.chemphyslip.2018.01.004 2018-01-11 Proton magnetic resonance spectroscopy (MRS) with optimized relaxation time is an effective method to quantify hepatic fatty acid values and characterize steatosis. The aim of this study is to quantify the difference in hepatic lipid content with metabolic ch...
Novel lipids with three C18-fatty acid chains and an amino acid head group for pH-responsive and sustained antibiotic delivery 10.1016/j.chemphyslip.2017.12.007 2018-01-02 The acidic environment at bacterial infection sites is a potential external stimulus for targeted antibiotic delivery. This paper reports new biocompatible pH-sensitive lipids (PSLs) with three hydrocarbon tails, and a head group with a secondary amine and ca...
Molecule confirmation and structure characterization of pentatriacontatrienyl mycolate in Mycobacterium smegmatis 10.1016/j.chemphyslip.2017.12.006 2017-12-30 Mycobacterium smegmatis is often used to study the different components of mycobacterial cell wall. Mycolic acids are important components of mycobacterial cell wall that have been associated with virulence. Recently, a novel lipid containing mycolic acids ha...
Structural design of intrinsically fluorescent oxysterols 10.1016/j.chemphyslip.2017.12.005 2017-12-26 Oxysterols are oxidized derivatives of cholesterol with many important biological functions. Trafficking of oxysterols in and between cells is not well studied, largely due to the lack of appropriate oxysterol analogs. Intrinsically fluorescent oxysterols pre...
Local Anesthetics Induce Interdigitation and Thermotropic Changes in Dipalmitoylphosphatidylcholine Bilayers 10.1016/j.chemphyslip.2017.12.003 2017-12-21 The molecular mechanism underlying the action of local anesthetics is still elusive. Phenylethanol (PEtOH) is an ingredient of essential oils with a rose-like odor and has been used as a local anesthetic. In this work, we have explored the effect of PEtOH on ...
Cobalt and Nickel Affect the Fluidity of Negatively-Charged Biomimetic Membranes 10.1016/j.chemphyslip.2017.11.016 2017-12-13 Elevated levels of the essential trace metals cobalt and nickel are associated with a variety of toxic effects, which are not well-understood, and may involve interactions with the lipid membrane. Fluidity changes of biomimetic lipid membranes upon exposure t...
Uptake of Iron (III)-Ethylenediamine-N, N, N′, N′-tetraacetic Acid Complex by Phosphatidylcholine Lipid Film Part II. Effect of Film Curvature 10.1016/j.chemphyslip.2017.12.001 2017-12-11 Mixed micelles formed in a ternary-solute aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N′,N′-tetraacetic acid complex (Fe-edta) and 1,2-diheptanoyl-sn-glycero-3-phosphatidyl choline (DHPC) were studied and compared with the mixed adsorbed film rep...
Uptake of Iron (III)-Ethylenediamine-N,N,N′,N′-tetraacetic Acid Complex by Phosphatidylcholine Lipid Film Part I. Effect of Bulk pH 10.1016/j.chemphyslip.2017.12.002 2017-12-06 We studied a ternary solutes aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N′,N′-tetraacetic acid complex (Fe-edta), and 1,2-diheptanoyl-sn-glycero-3-phosphatidylcholine (DHPC)/air interface system to clarify the interactions between iron complexes...
Phase behavior in the biologically important oleic acid/sodium oleate/water system 10.1016/j.chemphyslip.2017.11.017 2017-12-02 The phase behavior in the oleic acid/sodium oleate/normal saline (0.15 M NaCl aqueous solution) system has been determined. For this purpose visual inspection of samples between crossed polarizers, and Small Angle X-ray diffraction was used to identify the va...
Ion-induced modification of the sucrose network and its impact on melting of freeze-dried liposomes. DSC and molecular dynamics study 10.1016/j.chemphyslip.2017.11.015 2017-11-24 Disaccharides play an important role in survival of anhydrobiotic organisms during extreme environmental conditions. A key protection feature is their capability to form the hydrogen bond (HB) network in a similar fashion as the one made by water. Since vario...

Improved Quantitative Fatty Acid Values with Correction of T2 Relaxation Time in Terminal Methyl Group: In Vivo Proton Magnetic Resonance Spectroscopy at Ultra High Field in Hepatic Steatosis

10.1016/j.chemphyslip.2018.01.004

2018-01-11

Proton magnetic resonance spectroscopy (MRS) with optimized relaxation time is an effective method to quantify hepatic fatty acid values and characterize steatosis. The aim of this study is to quantify the difference in hepatic lipid content with metabolic ch...

Novel lipids with three C18-fatty acid chains and an amino acid head group for pH-responsive and sustained antibiotic delivery

10.1016/j.chemphyslip.2017.12.007

2018-01-02

The acidic environment at bacterial infection sites is a potential external stimulus for targeted antibiotic delivery. This paper reports new biocompatible pH-sensitive lipids (PSLs) with three hydrocarbon tails, and a head group with a secondary amine and ca...

Molecule confirmation and structure characterization of pentatriacontatrienyl mycolate in Mycobacterium smegmatis

10.1016/j.chemphyslip.2017.12.006

2017-12-30

Mycobacterium smegmatis is often used to study the different components of mycobacterial cell wall. Mycolic acids are important components of mycobacterial cell wall that have been associated with virulence. Recently, a novel lipid containing mycolic acids ha...

Structural design of intrinsically fluorescent oxysterols

10.1016/j.chemphyslip.2017.12.005

2017-12-26

Oxysterols are oxidized derivatives of cholesterol with many important biological functions. Trafficking of oxysterols in and between cells is not well studied, largely due to the lack of appropriate oxysterol analogs. Intrinsically fluorescent oxysterols pre...

Local Anesthetics Induce Interdigitation and Thermotropic Changes in Dipalmitoylphosphatidylcholine Bilayers

10.1016/j.chemphyslip.2017.12.003

2017-12-21

The molecular mechanism underlying the action of local anesthetics is still elusive. Phenylethanol (PEtOH) is an ingredient of essential oils with a rose-like odor and has been used as a local anesthetic. In this work, we have explored the effect of PEtOH on ...

Cobalt and Nickel Affect the Fluidity of Negatively-Charged Biomimetic Membranes

10.1016/j.chemphyslip.2017.11.016

2017-12-13

Elevated levels of the essential trace metals cobalt and nickel are associated with a variety of toxic effects, which are not well-understood, and may involve interactions with the lipid membrane. Fluidity changes of biomimetic lipid membranes upon exposure t...

Uptake of Iron (III)-Ethylenediamine-N, N, N′, N′-tetraacetic Acid Complex by Phosphatidylcholine Lipid Film Part II. Effect of Film Curvature

10.1016/j.chemphyslip.2017.12.001

2017-12-11

Mixed micelles formed in a ternary-solute aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N′,N′-tetraacetic acid complex (Fe-edta) and 1,2-diheptanoyl-sn-glycero-3-phosphatidyl choline (DHPC) were studied and compared with the mixed adsorbed film rep...

Uptake of Iron (III)-Ethylenediamine-N,N,N′,N′-tetraacetic Acid Complex by Phosphatidylcholine Lipid Film Part I. Effect of Bulk pH

10.1016/j.chemphyslip.2017.12.002

2017-12-06

We studied a ternary solutes aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N′,N′-tetraacetic acid complex (Fe-edta), and 1,2-diheptanoyl-sn-glycero-3-phosphatidylcholine (DHPC)/air interface system to clarify the interactions between iron complexes...

Phase behavior in the biologically important oleic acid/sodium oleate/water system

10.1016/j.chemphyslip.2017.11.017

2017-12-02

The phase behavior in the oleic acid/sodium oleate/normal saline (0.15 M NaCl aqueous solution) system has been determined. For this purpose visual inspection of samples between crossed polarizers, and Small Angle X-ray diffraction was used to identify the va...

Ion-induced modification of the sucrose network and its impact on melting of freeze-dried liposomes. DSC and molecular dynamics study

10.1016/j.chemphyslip.2017.11.015

2017-11-24

Disaccharides play an important role in survival of anhydrobiotic organisms during extreme environmental conditions. A key protection feature is their capability to form the hydrogen bond (HB) network in a similar fashion as the one made by water. Since vario...