Latest Articles of Chemistry and Physics of Lipids


Role of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) in β-lactoglobulin aggregation 10.1016/j.chemphyslip.2017.11.007 2017-11-08 Protein aggregation is a prevalent phenomenon. It is important to study protein aggregation under different solution conditions. In this study, using 1-anilinonaphthalene-8-sulfonic acid (ANS) fluorescence spectra, we investigated the critical micelle concent...
MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface 10.1016/j.chemphyslip.2017.11.004 2017-11-06 Most modern laundry detergents contain enzymes such as proteases, amylases, and lipases for more efficient removal of stains containing proteins, carbohydrates, and lipids during wash at low temperature. The function of the lipases is to hydrolyse the hydroph...
Microfluidic device as a facile in vitro tool to generate and investigate lipid gradients 10.1016/j.chemphyslip.2017.10.007 2017-11-02 This work describes a method that utilizes a microfluidic gradient generator to develop lateral lipid gradients in supported lipid bilayers (SLB). The new methodology provides freedom of choice with respect to the lipid composition of the SLB. In addition, th...
The interaction of phospholipase A2 with oxidized phospholipids at the lipid-water surface with different structural organization 10.1016/j.chemphyslip.2017.10.010 2017-10-31 Phospholipase A2 (PLA2 IB) activity towards UV-irradiated (λ = 180–400 nm) phospholipids in comparison to non-irradiated ones was investigated using phosphatidylcholine (PC) liposomes and mixed micelles of phosphatidylcholine and sodium deoxycholate as a memb...
A closer look at the behaviour of milk lipids during digestion 10.1016/j.chemphyslip.2017.10.009 2017-10-31 Milk has recently been reported to form complex self-assembled liquid crystalline structures during digestion by lipolytic enzymes. The formation of cubic phases at the endpoint of digestion was of particular interest as this requires a fine balance in self-a...
The effect of membrane softeners on rigidity of lipid vesicle bilayers: Derivation from vesicle size changes 10.1016/j.chemphyslip.2017.10.008 2017-10-28 Deformability is not just a fundamentally interesting vesicle characteristic; it is also the key determinant of vesicle ability to cross the skin barrier; i.e. skin penetrability. Development of bilayer vesicles for drug and vaccine delivery across the skin s...
Fliposomes: trans-2-aminocyclohexanol-based amphiphiles as pH-sensitive conformational switches of liposome membrane – a structure-activity relationship study 10.1016/j.chemphyslip.2017.10.004 2017-10-28 Recently developed lipids with the trans-2-aminocyclohexanol (TACH) moiety represent unique pH-sensitive conformational switches (“flipids”) that can trigger the membrane of liposome-based drug delivery systems at lowered pH as seen in many pathological scena...
Shipment of a photodynamic therapy agent into model membrane and its controlled release: A photophysical approach 10.1016/j.chemphyslip.2017.10.005 2017-10-19 Harmine, an efficient cancer cell photosensitizer (PS), emits intense violet color when it is incorporated in well established self assembly based drug carrier formed by cationic surfactants of identical positive charge of head group but varying chain length,...
Membrane-induced organization and dynamics of the N-terminal domain of chemokine receptor CXCR1: insights from atomistic simulations 10.1016/j.chemphyslip.2017.09.003 2017-09-20 The CXC chemokine receptor 1 (CXCR1) is an important member of the G protein-coupled receptor (GPCR) family in which the extracellular N-terminal domain has been implicated in ligand binding and selectivity. The structure of this domain has not yet been eluci...
Non-natural lipids: Synthesis and characterization of esters from meta-carborane-1-carboxylic acid 10.1016/j.chemphyslip.2017.08.008 2017-09-01 Lipids are defined as apolar molecules comprising as major classes fatty acids and fatty acid esters of normally natural origin. Non-natural components, such as dicarba-closo-dodecaboranes (in short carboranes) can also form acids and esters, which reveal lip...

Role of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) in β-lactoglobulin aggregation

10.1016/j.chemphyslip.2017.11.007

2017-11-08

Protein aggregation is a prevalent phenomenon. It is important to study protein aggregation under different solution conditions. In this study, using 1-anilinonaphthalene-8-sulfonic acid (ANS) fluorescence spectra, we investigated the critical micelle concent...

MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

10.1016/j.chemphyslip.2017.11.004

2017-11-06

Most modern laundry detergents contain enzymes such as proteases, amylases, and lipases for more efficient removal of stains containing proteins, carbohydrates, and lipids during wash at low temperature. The function of the lipases is to hydrolyse the hydroph...

Microfluidic device as a facile in vitro tool to generate and investigate lipid gradients

10.1016/j.chemphyslip.2017.10.007

2017-11-02

This work describes a method that utilizes a microfluidic gradient generator to develop lateral lipid gradients in supported lipid bilayers (SLB). The new methodology provides freedom of choice with respect to the lipid composition of the SLB. In addition, th...

The interaction of phospholipase A2 with oxidized phospholipids at the lipid-water surface with different structural organization

10.1016/j.chemphyslip.2017.10.010

2017-10-31

Phospholipase A2 (PLA2 IB) activity towards UV-irradiated (λ = 180–400 nm) phospholipids in comparison to non-irradiated ones was investigated using phosphatidylcholine (PC) liposomes and mixed micelles of phosphatidylcholine and sodium deoxycholate as a memb...

A closer look at the behaviour of milk lipids during digestion

10.1016/j.chemphyslip.2017.10.009

2017-10-31

Milk has recently been reported to form complex self-assembled liquid crystalline structures during digestion by lipolytic enzymes. The formation of cubic phases at the endpoint of digestion was of particular interest as this requires a fine balance in self-a...

The effect of membrane softeners on rigidity of lipid vesicle bilayers: Derivation from vesicle size changes

10.1016/j.chemphyslip.2017.10.008

2017-10-28

Deformability is not just a fundamentally interesting vesicle characteristic; it is also the key determinant of vesicle ability to cross the skin barrier; i.e. skin penetrability. Development of bilayer vesicles for drug and vaccine delivery across the skin s...

Fliposomes: trans-2-aminocyclohexanol-based amphiphiles as pH-sensitive conformational switches of liposome membrane – a structure-activity relationship study

10.1016/j.chemphyslip.2017.10.004

2017-10-28

Recently developed lipids with the trans-2-aminocyclohexanol (TACH) moiety represent unique pH-sensitive conformational switches (“flipids”) that can trigger the membrane of liposome-based drug delivery systems at lowered pH as seen in many pathological scena...

Shipment of a photodynamic therapy agent into model membrane and its controlled release: A photophysical approach

10.1016/j.chemphyslip.2017.10.005

2017-10-19

Harmine, an efficient cancer cell photosensitizer (PS), emits intense violet color when it is incorporated in well established self assembly based drug carrier formed by cationic surfactants of identical positive charge of head group but varying chain length,...

Membrane-induced organization and dynamics of the N-terminal domain of chemokine receptor CXCR1: insights from atomistic simulations

10.1016/j.chemphyslip.2017.09.003

2017-09-20

The CXC chemokine receptor 1 (CXCR1) is an important member of the G protein-coupled receptor (GPCR) family in which the extracellular N-terminal domain has been implicated in ligand binding and selectivity. The structure of this domain has not yet been eluci...

Non-natural lipids: Synthesis and characterization of esters from meta-carborane-1-carboxylic acid

10.1016/j.chemphyslip.2017.08.008

2017-09-01

Lipids are defined as apolar molecules comprising as major classes fatty acids and fatty acid esters of normally natural origin. Non-natural components, such as dicarba-closo-dodecaboranes (in short carboranes) can also form acids and esters, which reveal lip...