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Handheld skin printer: in situ formation of planar biomaterials and tissues
10.1039/C7LC01236E 2018-04-11 We present a handheld skin printer that enables the in situ formation of biomaterial and skin tissue sheets of different homogeneous and architected compositions. When manually positioned above a target surface, the compact instrument (weight <0.8 kg) conform... |
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A microfluidic biochip platform for electrical quantification of proteins
10.1039/C8LC00033F 2018-04-10 Sepsis, an adverse auto-immune response to an infection often causing life-threatening complications, results in the highest mortality and treatment cost of any illness in US hospitals. Several immune biomarker levels, including Interleukin 6 (IL-6), have sho... |
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A simple microfluidic platform for rapid and efficient production of the radiotracer [18F]fallypride
10.1039/C8LC00167G 2018-04-09 Herein, we report the development of a simple, high-throughput and efficient microfluidic system for synthesizing radioactive [18F]fallypride, a PET imaging radiotracer widely used in medical research. The microfluidic chip contains all essential modules requ... |
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Fully automated, on-site isolation of cfDNA from whole blood for cancer therapy monitoring
10.1039/C8LC00165K 2018-04-09 The potential utility of circulating tumour DNA (ctDNA) in patient blood for cancer diagnostics and real-time monitoring of disease progression is highly recognized. However, the lack of automated and efficient methods for cell-free DNA (cfDNA) isolation from... |
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Long-term C. elegans immobilization enables high resolution developmental studies in vivo
10.1039/C7LC01185G 2018-04-06 Live-imaging of C. elegans is essential for the study of conserved cellular pathways (e.g. EGFR/Wnt signaling) and morphogenesis in vivo. However, the usefulness of live imaging as a research tool has been severely limited by the need to immobilize worms prio... |
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Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
10.1039/C7LC01357D 2018-04-05 Chronic lung diseases (CLDs) are regulated by complex interactions between many different cell types residing in lung airway tissues. Specifically, interactions between airway epithelial cells (ECs) and airway smooth muscle cells (SMCs) have been shown in par... |
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“Dip-and-read” paper-based analytical devices using distance-based detection with colour screening
10.1039/C8LC00168E 2018-04-05 An improved microfluidic paper-based analytical device (PAD) using colour screening to enhance device performance is described. Current detection methods for PADs relying on the distance-based signaling motif can be slow due to the assay time being limited by... |
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Microsensor systems for cell metabolism – from 2D culture to organ-on-chip
10.1039/C7LC00942A 2018-04-05 Microsensor systems for cell metabolism are essential tools for investigation and standardization in cell culture. Electrochemical and optical read-out schemes dominate, which enable the marker-free, continuous, online recording of transient effects and deliv... |
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3D nanofabrication inside rapid prototyped microfluidic channels showcased by wet-spinning of single micrometre fibres
10.1039/C7LC01366C 2018-04-03 Microfluidics is an established multidisciplinary research domain with widespread applications in the fields of medicine, biotechnology and engineering. Conventional production methods of microfluidic chips have been limited to planar structures, preventing t... |
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Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy
10.1039/C7LC01301A 2018-03-31 The rapid screening and isolation of single leukemia cells from blood has become critical for early leukemia detection and tumor heterogeneity interrogation. However, due to the size overlap between leukemia cells and the more abundant white blood cells (WBCs... |