SL910102

Modify Date: 2024-01-08 18:24:20

SL910102 Structure
SL910102 structure
Common Name SL910102
CAS Number 144756-71-8 Molecular Weight 490.60
Density N/A Boiling Point N/A
Molecular Formula C30H30N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SL910102


SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.

 Names

Name SL910102

 SL910102 Biological Activity

Description SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.
Related Catalog
Target

Angiotensin AT1 receptor[1]

In Vitro SL910102 (SL 91.0102-90 DL) is a unlabelled nonpeptide AT1-antagonist, which is tested for its ability to compete with [125J](Sar1-Ile8)-angiotensin II for specific AT1-receptor sites in rat lung homogenate[1].
Kinase Assay For saturation as well as displacement studies, rat lung homogenate is incubated in either Hepes-buffer or blank human or rat plasma yielding 50 μg protein per well in a total assay volume of 300 μL. To ensure equilibrium conditions (see binding kinetics), the samples are maintained for 60 min at 25°C under continuous rotation. All experiments are carried out in duplicate, and the results are confirmed with n=3-5 replicates over the following days[1].
References

[1]. Soldner A, et al. A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites. J Pharm Biomed Anal. 1998 May;17(1):111-24.

 Chemical & Physical Properties

Molecular Formula C30H30N6O
Molecular Weight 490.60
Storage condition 2-8℃
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