Nitroxazepine
Modify Date: 2024-01-11 01:12:05
Nitroxazepine structure
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Common Name | Nitroxazepine | ||
|---|---|---|---|---|
| CAS Number | 47439-36-1 | Molecular Weight | 341.361 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 514.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H19N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 264.8±30.1 °C | |
Use of NitroxazepineNitroxazepine is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor. |
| Name | Nitroxazepine |
|---|---|
| Synonym | More Synonyms |
| Description | Nitroxazepine is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor. |
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| Related Catalog | |
| Target |
serotonin-norepinephrine reuptake |
| In Vitro | The in vitro effect of Nitroxazepine (Sintamil), as a modulator alone and in combination with hydroxyurea (HU), on cytotoxicity is studied in 16 cases of human chronic myeloid leukemia (CML). The cytotoxicity of the drugs as a function of the exposure dose (HU, 100 μM; Nitroxazepine, 10 μg/mL) and the exposure time (1 h) to the agent is investigated. Cytotoxicity is evaluated as the inhibition of incorporation of [3H-methyl]thymidine in the nucleic acids of CML cells. Cytotoxicity of HU is greatly enhanced (P<0.001) by 1 h exposure of the CML cells to Nitroxazepine. The present data indicate that Nitroxazepine potentiates the cytotoxic activity of HU in CML cells[1]. Nitroxazepine is indicated for the treatment of nocturnal enuresis. Nitroxazepine has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 514.3±50.0 °C at 760 mmHg |
| Molecular Formula | C18H19N3O4 |
| Molecular Weight | 341.361 |
| Flash Point | 264.8±30.1 °C |
| Exact Mass | 341.137543 |
| LogP | 2.41 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.606 |
| Storage condition | 2-8℃ |
| CNU9GY55SI |
| 10-[3-(Dimethylamino)propyl]-2-nitrodibenzo[b,f][1,4]oxazepin-11(10H)-one |
| Dibenz[b,f][1,4]oxazepin-11(10H)-one, 10-[3-(dimethylamino)propyl]-2-nitro- |
| Nitroxazepine |