2-chloroacetonitrile
Names
[ CAS No. ]:
107-14-2
[ Name ]:
2-chloroacetonitrile
[Synonym ]:
2-chloroacetonitrile
EINECS 203-467-0
MFCD00001885
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
126.5±0.0 °C at 760 mmHg
[ Melting Point ]:
38℃
[ Molecular Formula ]:
C2H2ClN
[ Molecular Weight ]:
75.497
[ Flash Point ]:
47.8±0.0 °C
[ Exact Mass ]:
74.987579
[ PSA ]:
23.79000
[ LogP ]:
0.14
[ Vapour density ]:
3 (vs air)
[ Vapour Pressure ]:
11.6±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.400
[ Stability ]:
Stable, but reacts with water. Combustible. Incompatible with water, moisture, strong oxidizing agents, acids.
[ Water Solubility ]:
INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AL8225000
- CHEMICAL NAME :
- Acetonitrile, chloro-
- CAS REGISTRY NUMBER :
- 107-14-2
- BEILSTEIN REFERENCE NO. :
- 0506028
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C2-H2-Cl-N
- MOLECULAR WEIGHT :
- 75.50
- WISWESSER LINE NOTATION :
- NC1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 139 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 71 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4800 mg/kg/2W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 79100 nmol/L
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,1065,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H301 + H311 + H331-H411
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P210-P280-P302 + P352 + P312-P304 + P340 + P312-P370 + P378
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R23/24/25;R51/53
[ Safety Phrases ]:
S45-S61
[ RIDADR ]:
UN 2668 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AL8225000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
2926909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Environ. Mol. Mutagen. 36(1) , 52-8, (2000)
Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have c...
Percutaneous absorption of haloacetonitriles and chloral hydrate and simulated human exposures.J. Appl. Toxicol. 32(6) , 387-94, (2012)
Disinfection-by-products (DBPs) have long been a human health concern and many are known carcinogens and teratogens. Skin is exposed to DBPs in water through bathing and swimming; however, dermal upta...
Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse.Toxicol. Ind. Health 24(8) , 511-8, (2008)
Chloroacetonitrile (CAN) is a by-product of chlorination of drinking water. Epidemiological studies indicate that it might present a hazard to human health. The present study was designed to investiga...