2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

Names

[ CAS No. ]:
112-60-7

[ Name ]:
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

[Synonym ]:
2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
Tetra(ethylene glycol)
2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol
MFCD00002879
Tetraglycol
Ethyl acetate
Tetraethylene glycol
2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol
EINECS 203-989-9
Bis[2-(2-hydroxyethoxy)ethyl] ether
Bis[2-(2-hydroxyethoxy)ethyl]ether
tetraethylene glycol-
tetraethyleneglycol
Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
PEG-4

Biological Activity

[Description]:

PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
328.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-5.6 °C(lit.)

[ Molecular Formula ]:
C₈H₁₈O₅

[ Molecular Weight ]:
194.225

[ Flash Point ]:
176.7±0.0 °C

[ Exact Mass ]:
194.115417

[ PSA ]:
68.15000

[ LogP ]:
-2.23

[ Vapour density ]:
6.7 (vs air)

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.455

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XC2100000

CHEMICAL NAME :: Tetraethylene glycol

CAS REGISTRY NUMBER :: 112-60-7

BEILSTEIN REFERENCE NO. :: 1634320

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H18-O5

MOLECULAR WEIGHT :: 194.26

WISWESSER LINE NOTATION :: Q2O2O2O2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28900 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0987-0693 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84662 No. of Facilities: 206 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 1685 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84662 No. of Facilities: 3704 (estimated) No. of Industries: 40 No. of Occupations: 44 No. of Employees: 55282 (estimated) No. of Female Employees: 1585 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
C

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
XC2100000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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Related Compounds

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