8-Azaadenine
Names
[ CAS No. ]:
1123-54-2
[ Name ]:
8-Azaadenine
[Synonym ]:
2H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine
8-Azaadenine
1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine
EINECS 214-375-5
2H-[1,2,3]Triazolo[4,5-d]pyrimidin-7-amine
MFCD00005697
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Boiling Point ]:
563.9±30.0 °C at 760 mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C4H4N6
[ Molecular Weight ]:
136.115
[ Flash Point ]:
329.4±11.8 °C
[ Exact Mass ]:
136.049744
[ PSA ]:
93.37000
[ LogP ]:
-0.88
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.875
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XZ5680000
- CHEMICAL NAME :
- 1H-v-Triazolo(4,5-d)pyrimidin-7-amine
- CAS REGISTRY NUMBER :
- 1123-54-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C4-H4-N6
- MOLECULAR WEIGHT :
- 136.14
- WISWESSER LINE NOTATION :
- T56 BMNN FN HNJ IZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 315 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 20 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
XZ5680000
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Toxicol. Sci. 141(1) , 300-13, (2014)
Epidemiological studies have demonstrated extensive human exposure to the monocyclic aromatic amines, particularly to 3,5-dimethylaniline, and found an association between exposure to these compounds ...
Intersystem crossing to excited triplet state of aza analogues of nucleic acid bases in acetonitrile.J. Phys. Chem. A 113(44) , 12088-93, (2009)
Excited state characteristics of aza analogues of nucleic acid bases, 8-azaadenine (8AA), 5-azacytosine (5AC), 8-azaguanine (8AG), and 6-azauracil (6AU), in acetonitrile solution were comprehensively ...
[Effects of 5-bromouracil and 5-bromodeoxyuridine in combination with 8-aza-adenine on the UV sensitivity of bacteria].Z. Allg. Mikrobiol. 23(8) , 495-501, (1983)
The presence of 5-bromouracil (BU) as well as 5-bromo-2-deoxyuridine (BUdR) in the cultivation media of bacteria results in the distinct increase of UV sensitivity. With the nucleic acid base analogue...