bromfenvinphos-methyl
Names
[ CAS No. ]:
13104-21-7
[ Name ]:
bromfenvinphos-methyl
[Synonym ]:
Polphos
Methylbromphenvinphos
Polfos
IPO 63
Shell SD-8988
METHYLBROMFENVINPHOS
Bromfenvinphos-methyl
ENT 27,043
Chemical & Physical Properties
[ Density]:
1.63g/cm3
[ Boiling Point ]:
382.2ºC at 760mmHg
[ Molecular Formula ]:
C10H10BrCl2O4P
[ Molecular Weight ]:
375.96800
[ Flash Point ]:
185ºC
[ Exact Mass ]:
373.88800
[ PSA ]:
54.57000
[ LogP ]:
5.10420
[ Vapour Pressure ]:
1.05E-05mmHg at 25°C
[ Index of Refraction ]:
1.564
[ Storage condition ]:
APPROX 4°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TB8460000
- CHEMICAL NAME :
- Phosphoric acid, 2-bromo-1-(2,4-dichlorophenyl)vinyl dimethyl ester
- CAS REGISTRY NUMBER :
- 13104-21-7
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C10-H10-Br-Cl2-O4-P
- MOLECULAR WEIGHT :
- 375.98
- WISWESSER LINE NOTATION :
- GR CG DYU1EOPO&O1&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 9,283,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 32,507,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 405 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 31,575,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 792 mg/kg/12W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 19,61,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1134 mg/kg/28D-I
- TOXIC EFFECTS :
- Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 31,575,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1536 mg/kg/17W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 32,507,1981
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36
[ RIDADR ]:
UN2811 6.1/PG 3
[ RTECS ]:
TB8460000
[ HS Code ]:
2919900090
Customs
[ HS Code ]: 2919900090
[ Summary ]:
2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
Articles
J. Biochem. Biophys. Methods 7(2) , 171-3, (1983)
The effect of methylbromophenvinfos (Polfos) on some enzymes in vivo and in vitro. I. In vivo studies.
Pol. J. Pharmacol. Pharm. 39(4) , 361-70, (1987)
The experiment was carried out on Wistar rats receiving orally either oil or oily solution of methylbromophenvinfos (Polfos) either in a single dose of 0.5 LD50, or doses of 0.1 LD50 once daily for a ...
Excretion and peripheral metabolism of 1, 2-3H-testosterone and androgens in rats following intoxication with organophosphorous insecticides. 1--Acute exposure.J. Appl. Toxicol. 4(5) , 261-4, (1984)
The effects of methylbromphenvinfos (MBFV) and fenitrothion on androgen levels, excretion and peripheral metabolism were studied in male rats. The insecticides were administered orally in high, single...