1,N6-ETHENOADENINE

[ Density]:
1.78g/cm3

[ Molecular Formula ]:
C₇H₅N₅

[ Molecular Weight ]:
159.14800

[ Exact Mass ]:
159.05400

[ PSA ]:
58.87000

[ LogP ]:
0.60560

[ Index of Refraction ]:
1.956

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Precursor

DownStream

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.

Toxicol. Lett. 155(3) , 403-10, (2005)

5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to rep...

Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.

PLoS ONE 7(12) , e51776, (2012)

Oxygen free radicals induce lipid peroxidation (LPO) that damages and breaks polyunsaturated fatty acids in cell membranes. LPO-derived aldehydes and hydroxyalkenals react with DNA leading to the form...

Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase.

J. Biol. Chem. 281(40) , 29525-32, (2006)

N-Methylpurine-DNA glycosylase (MPG) initiates base excision repair in DNA by removing a wide variety of alkylated, deaminated, and lipid peroxidation-induced purine adducts. MPG activity and other DN...

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