4-Nitrophenyl N-acetyl-β-D-galactosaminide

Names

[ Name ]:
4-Nitrophenyl N-acetyl-β-D-galactosaminide

[Synonym ]:
EINECS 239-024-3
MFCD00150920
4-Nitrophenyl 2-acetamido-2-deoxy-β-D-galactopyranoside
4-nitrophenyl N-acetyl-beta-D-galactosaminide
4-Nitrophenyl-N-acetyl-β-D-galactosaminide
4-Nitrophenyl 2-Acetamido-2-deoxy-β-<small>D</small>-galactopyranoside
4-Nitrophenyl N-acetyl-β-D-galactosaminide
β-D-Galactopyranoside, 4-nitrophenyl 2-(acetylamino)-2-deoxy-

Biological Activity

[Description]:

4-Nitrophenyl-N-acetyl-β-D-galactosaminide has inhibitory activity against GlcNAc and GalNAc with Kis of 1.15 mM and 0.51 mM, respectively. 4-Nitrophenyl-N-acetyl-β-D-galactosaminide is extracted from Trichomonas foetus (T. foetus)[1]

[Related Catalog]:

Research Areas >> Cancer

[Target]

Ki: 1.15 mM (GlcNAc), 0.51 mM (GalNAc)[1]

[References]

[1]. Edwards RG, et al. The purification and properties of a beta-N-acetylhexosaminidase from Trichomonas foetus. Biochem J. 1975 Oct;151(1):145-8. doi: 10.1042/bj1510145

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
694.7±55.0 °C at 760 mmHg

[ Melting Point ]:
181ºC

[ Molecular Formula ]:
C₁₄H₁₈N₂O₈

[ Molecular Weight ]:
342.301

[ Flash Point ]:
374.0±31.5 °C

[ Exact Mass ]:
342.106323

[ PSA ]:
154.07000

[ LogP ]:
0.00

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMF: 50 mg/mL, clear, yellow-green

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Binding of simple carbohydrates and some of their chromophoric derivatives to soybean agglutinin as followed by titrimetric procedures and stopped flow kinetics.

J. Biol. Chem. 259(11) , 7067-74, (1984)

The number of carbohydrate-binding sites of the GalNAc-specific lectin is four per tetramer. The binding parameters of N-acetyl-D-galactosamine and methyl-N-acetyl-alpha-D- galactosaminide , were dete...

Syntheses of the 3- and 4-thio analogues of 4-nitrophenyl 2-acetamido-2-deoxy-beta-D-gluco- and galactopyranoside.

Carbohydr. Res. 342(15) , 2212-22, (2007)

The syntheses of 4-nitrophenyl beta-glycosides of the 3-thio and 4-thio analogues of the two principal 2-acetamido-2-deoxy-hexoses found in living systems, GlcNAc and GalNAc, are described. While synt...

Chitin oligosaccharide synthesis by rhizobia and zebrafish embryos starts by glycosyl transfer to O4 of the reducing-terminal residue.

Biochemistry 38(13) , 4045-52, (1999)

Lipochitin oligosaccharides are organogenesis-inducing signal molecules produced by rhizobia to establish the formation of nitrogen-fixing root nodules in leguminous plants. Chitin oligosaccharide bio...

Related Compounds

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