D-Menthol

Names

[ Name ]:
D-Menthol

[Synonym ]:
1S,3S,4R-(+)-menthol
(1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexanol
Menthol, (1S,3S,4R)-(+)-
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-
Cyclohexanol, 5-methyl-2- (1-methylethyl)-, (1α,2β,5α)-
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1α,2β,5α)-
MFCD00062983
(1S,2R,5S)-2-Isopropyl-5-methylcyclohexanol
Menthol
(+)-Menthol
(+)-p-Menthan-3-ol
EINECS 239-387-8

Biological Activity

[Description]:

(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

(+)-Menthol (0.0001-0.1 μg/ml) reduces the electrically evoked contractions of rat phrenic hemidiaphragm dose-dependently in vitro, up to complete abolishment of contractions. [1].

[References]

[1]. Galeotti N, et al. Local anaesthetic activity of (+)- and (-)-menthol. Planta Med. 2001 Mar;67(2):174-6.

[2]. Galeotti N, et al. Menthol: a natural analgesic compound. Neurosci Lett. 2002 Apr 12;322(3):145-8.

[3]. Hu X, et al. Effects of d-menthol stress on the growth of and microcystin release by the freshwater cyanobacterium Microcystis aeruginosa FACHB-905. Chemosphere. 2014 Oct;113:30-5.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
215.4±8.0 °C at 760 mmHg

[ Melting Point ]:
43-44ºC

[ Molecular Formula ]:
C₁₀H₂₀O

[ Molecular Weight ]:
156.265

[ Flash Point ]:
93.3±0.0 °C

[ Exact Mass ]:
156.151413

[ PSA ]:
20.23000

[ LogP ]:
3.20

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.457

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R37/38;R41

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
OT0700000

[ HS Code ]:
2906199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2906199090

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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Related Compounds

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