MQAE

Names

[ Name ]:
MQAE

[Synonym ]:
(6-Methoxyquinolinio)acetic acid ethyl ester bromide,MQAE
(6-Methoxyquinolinio)acetic acid ethyl ester bromide MQAE
ethyl 2-(6-methoxyquinolin-1-ium-1-yl)acetate,bromide
MQAE

Biological Activity

[Description]:

MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[In Vitro]

Bath-applied to acute brain slices, MQAE provides high-quality labeling of neuronal cells and their processes[1]. MQAE fluorescence is adequate and comparable method for measuring cAMP-dependent chloride transport in individual cells[2]. MQAE can be used to measure intracellular chloride concentration in primary cultures of rat aortic smooth muscle cells (VSMC)[3].

[References]

[1]. Kovalchuk Y, et al. Two-photon chloride imaging using MQAE in vitro and in vivo. Cold Spring Harb Protoc. 2012 Jul 1;2012(7):778-85.

[2]. Andersson C, et al. Determination of chloride efflux by X-ray microanalysis versus MQAE-fluorescence. Microsc Res Tech. 2002 Dec 15;59(6):531-5.

[3]. Koncz C, et al. Use of MQAE for measurement of intracellular [Cl-] in cultured aortic smooth muscle cells. Am J Physiol. 1994 Dec;267(6 Pt 2):H2114-23.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
177-179ºC(lit.)

[ Molecular Formula ]:
C₁₄H₁₆BrNO₃

[ Molecular Weight ]:
326.18600

[ Exact Mass ]:
325.03100

[ PSA ]:
39.41000

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications.

Anal. Biochem. 178 , 355, (1989)

A class of N-substituted quinoline compounds has been introduced recently for the fluorescence measurement of Cl concentration in biological preparations. The most Cl-sensitive compound was 6-methoxy-...

Hypoxia inhibits colonic ion transport via activation of AMP kinase.

Ann. Surg. 254 , 957-963, (2011)

Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mu...

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders.

Hepatology 50 , 861-870, (2009)

TGR5 (Gpbar-1) is a plasma membrane-bound, G protein-coupled receptor for bile acids. TGR5 messenger RNA (mRNA) has been detected in many tissues, including rat cholangiocytes and mouse gallbladder. A...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.