3-Hydroxy Carbofuran

Names

[ Name ]:
3-Hydroxy Carbofuran

[Synonym ]:
methylcarbamic acid 2,2-dimethyl-3-hydroxy-2,3-dihydrobenzofuran-7-yl ester
2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl methylcarbamate
Carbamic acid,methyl-,2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester
Methylcarbamic acid 2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester
Carbofuran-3-hydroxy solution
T56 BOT&J C1 C1 DQ IOVM1
MFCD00143168
3,7-Benzofurandiol, 2,3-dihydro-2,2-dimethyl-, 7-(methylcarbamate)
Carbofuran-3-hydroxy
2,3-dihydro-2,2-dimethyl-3-hydroxybenzofuran-7-yl methylcarbamate
3-Hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate
3-Hydroxycarbofuran
3-Hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofur-7-yl-methylcarbamat
3-hydroxy-2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
2,3-Dihydro-2,2-dimethyl-3,7-benzofurandiol 7-(methylcarbamate)

Biological Activity

[Description]:

3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Duraisamy Kempuraj, et al. Carbofuran pesticide toxicity to the eye. Exp Eye Res. 2023 Feb;227:109355.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
344.7±42.0 °C at 760 mmHg

[ Melting Point ]:
140-148ºC

[ Molecular Formula ]:
C₁₂H₁₅NO₄

[ Molecular Weight ]:
237.25

[ Flash Point ]:
162.2±27.9 °C

[ Exact Mass ]:
237.100113

[ PSA ]:
67.79000

[ LogP ]:
0.21

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.553

[ Storage condition ]:
APPROX 4°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FB9500000

CHEMICAL NAME :: Carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl ester

CAS REGISTRY NUMBER :: 16655-82-6

BEILSTEIN REFERENCE NO. :: 1383873

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H15-N-O4

MOLECULAR WEIGHT :: 237.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 mg/L

REFERENCE :: TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 18(1),17,1984

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300

[ Precautionary Statements ]:
P264-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+,Xi,F

[ Risk Phrases ]:
R28

[ Safety Phrases ]:
S28

[ RIDADR ]:
UN 2757

[ RTECS ]:
FB9500000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Determination of pesticides in soy-based infant formula using liquid chromatography with electrospray ionization tandem mass spectrometry.

J. AOAC Int. 89(1) , 214-24, (2006)

A sensitive method using liquid chromatography with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) was developed and validated to quantify and confirm 13 pesticides, including aldicar...

Metabolism of carbofuran by Aspergillus niger and Fusarium graminearum.

J. Environ. Sci. Health B 33(3) , 253-66, (1998)

Metabolism of carbofuran in pure liquid cultures of A. niger and F. graminearum was investigated. Carbofuran and its metabolites were analyzed by HPLC and TLC. The average recoveries of carbofuran, 3-...

Surprising hair analysis results following acute carbofuran intoxication.

Forensic Sci. Int. 212(1-3) , e10-4, (2011)

We present two non fatal cases of intoxication with carbofuran (CBF) documented by hair analysis. Carbofuran and 3-hydroxycarbofuran (OHCBF, its main metabolite) hair concentrations were determined us...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.