Bis(4-aminocyclohexyl)methane
Names
[ CAS No. ]:
1761-71-3
[ Name ]:
Bis(4-aminocyclohexyl)methane
[Synonym ]:
4,4-Methylenebiscyclohexylamine
hlr4448
4,4'-methanediyldicyclohexanamine
bis(para-amino-cyclohexyl)methane
Cyclohexanamine, 4,4'-methylenebis-
EINECS 217-168-8
Bis(4-aminocyclohexyl)methane
Wondamine HM
p-aminodicyclohexylmethane
DICYKAN
HLR 4219
4,4'-Methylenebis(aminocyclohexane)
4,4'-Methylenedicyclohexanamine
TRANS,TRANS-4,4'-METHYLENEBIS(CYCLOHEXYLAMINE)
4,4'-Methylenebis(cyclohexylaMine)
4,4'-Diaminodicyclohexylmethane
4,4'-methylene bis(cyclohexylamine)
4-((4-aminocyclohexyl)methyl)cyclohexanamine
Bis-(p-aminocyclohexyl)methane
MFCD00001496
di(4-aminocyclohexyl)-methane
4,4-Methylenebis(Cyclohexylamine)
bis-(4-amino cyclohexyl)-methane
PACM20
wandaminhm
Amicure PACM
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
320.0±0.0 °C at 760 mmHg
[ Melting Point ]:
60-65°C
[ Molecular Formula ]:
C13H26N2
[ Molecular Weight ]:
210.359
[ Flash Point ]:
144.8±17.9 °C
[ Exact Mass ]:
210.209595
[ PSA ]:
52.04000
[ LogP ]:
2.49
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.499
[ Water Solubility ]:
Insoluble (
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GX1530000
- CHEMICAL NAME :
- Cyclohexylamine, 4,4'-methylenebis-
- CAS REGISTRY NUMBER :
- 1761-71-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C13-H26-N2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 670 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571204
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,481,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 20175 mg/kg/1.5Y-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration Kidney, Ureter, Bladder - interstitial nephritis
- REFERENCE :
- JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 11,367,1991
Safety Information
[ Symbol ]:
GHS05, GHS07, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H314-H317-H373-H411
[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;
[ Risk Phrases ]:
R26;R34;R51/53
[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S61
[ RIDADR ]:
UN 2928 6.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
GX1530000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2921300090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Preparation
Customs
[ HS Code ]: 2921300090
[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Contact Dermatitis 48(6) , 305-9, (2003)
From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI)...
Toxicity of 1,4-bis(aminocyclohexyl)methane.J. Appl. Toxicol. 11(5) , 367-71, (1991)
1,4-Bis(aminocyclohexyl)methane (PACM; CAS No. 1761-71-3) is a white solid considered for use in polymeric systems. PACM is moderately toxic systemically, with the acute oral lethal dose in rats betwe...