5-Chlorooxindole
Names
[ CAS No. ]:
17630-75-0
[ Name ]:
5-Chlorooxindole
[Synonym ]:
5-Chlorooxindole
EINECS 412-200-9
2H-Indol-2-one, 5-chloro-1,3-dihydro-
5-chloroindolin-2-one
5-Chloro-1,3-dihydro-2H-indol-2-one
5-Chloro-2-oxindole
5-chloro-1,3-dihydroindol-2-one
5-Chloro-2-indolinone
MFCD00191927
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
348.3±42.0 °C at 760 mmHg
[ Melting Point ]:
194-197 °C(lit.)
[ Molecular Formula ]:
C8H6ClNO
[ Molecular Weight ]:
167.592
[ Flash Point ]:
164.5±27.9 °C
[ Exact Mass ]:
167.013794
[ PSA ]:
29.10000
[ LogP ]:
2.12
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.602
[ Storage condition ]:
Keep Cold
MSDS
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H317-H361f-H412
[ Precautionary Statements ]:
P273-P280
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38;R43;R62
[ Safety Phrases ]:
S22-S36/37-S61-S45-S36/37/39-S24
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ HS Code ]:
2933790090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933790090
[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%
Articles
J. Pharm. Biomed. Anal. 14(7) , 825-33, (1996)
5-Chlorooxindole (5-CO) is a starting material for tenidap sodium, a pharmaceutical drug candidate produced by Pfizer. To insure potency and purity of the drug substance, it is necessary to demonstrat...
Synthesis and biological evaluation of new pyridone-annelated isoindigos as anti-proliferative agents.Molecules 19(9) , 13076-92, (2014)
A selected set of substituted pyridone-annelated isoindigos 3a-f has been synthesized via interaction of 5- and 6-substituted oxindoles 2a-f with 6-ethyl-1,2,9-trioxopyrrolo[3,2-f]quinoline-8-carboxyl...