4-methylumbelliferyl β-D-glucoside

Names

[ Name ]:
4-methylumbelliferyl β-D-glucoside

[Synonym ]:
7-hydroxy-4-methyl-8-nitro-chromen-2-one
4-methylumbelliferyl β-D-glucoside
4-Methyl-2-oxo-2H-chromen-7-yl β-D-glucopyranoside
4-methyl-7-hydroxy-8-nitro coumarin
EINECS 228-185-5
4-methyl-8-nitro-7-hydroxycoumarin
4-Methylumbelliferyl-beta-D-glucopyranoside
MFCD00036773
2H-1-Benzopyran-2-one, 7-(β-D-glucopyranosyloxy)-4-methyl-
mutanolysin
7-Hydroxy-4-methyl-8-nitro-cumarin
(4-Methylumbelliferone)-β-D-glucopyranoside
7-hydroxy-4-methyl-8-nitro-coumarin
7-hydroxy-8-nitro-4-methyl-2H-chromen-2-one
4-Methylumbelliferyl β-D-glucopyranoside

Biological Activity

[Description]:

4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity[1]. 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively[2].

[Related Catalog]:

Research Areas >> Others

[Target]

4-Methylumbelliferyl β-D-Glucopyranoside is a fluorogenic substrate for β-glucosidase[1].

[References]

[1]. Smitka CM,et al. Rapid fluorogenic assay for differentiation of the Candida parapsilosis group from other Candida spp. J Clin Microbiol. 1989;27(1):203-206.

[2]. Oftedal L, et al. Validation and assessment of preanalytical factors of a fluorometric in vitro assay for glucocerebrosidase activity in human cerebrospinal fluid. Sci Rep. 2020;10(1):22098. Published 2020 Dec 16.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
626.9±55.0 °C at 760 mmHg

[ Melting Point ]:
258-263ºC (dec.)

[ Molecular Formula ]:
C₁₆H₁₈O₈

[ Molecular Weight ]:
338.309

[ Flash Point ]:
233.9±25.0 °C

[ Exact Mass ]:
338.100159

[ PSA ]:
129.59000

[ LogP ]:
-0.46

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
26/27/28

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Pediatr. Blood Cancer 62(3) , 522-8, (2015)

Increasing evidence suggests that early and rapid lymphocyte recovery following allogeneic hematopoietic stem cell transplantation (HSCT) is associated with better survival.We retrospectively analyzed...

Related Compounds

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