Aminoguanidine hydrochloride

Names

[ CAS No. ]:
1937-19-5

[ Name ]:
Aminoguanidine hydrochloride

[Synonym ]:
Aminoguanidine hydrochloride
AMINOGUANIDINE SALT
MFCD00039074
N1-aminoguanidine hydrochloride
Guanylhydrazine hydrochloride
aminoguanidinium chloride
Aminoguanidine hydrochoride
1-aminoguanidine hydrochloride
6-Hydroxydopamine hydrobromide
EINECS 217-707-7
D015 AMinoguanidine hydrochloride
GUANYLHYDRAZINEHCL
Aminoguanidine HCL
amino-guanidinhydrochloride
aminoguanidine monohydrochloride
Hydrazinecarboximidamide, hydrochloride (1:1)
Hydrazinecarboximidamide hydrochloride (1:1)
carbazamidine monohydrochloride
Aminoguanidine salts
GUANIDINE,AMINO-,MONOHYDROCHLORIDE
hydrazinecarboximidamide hydrochloride
Aminoguanidine (hydrochloride)

Biological Activity

[Description]:

Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Endocrinology

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
261.4ºC at 760 mmHg

[ Melting Point ]:
162-166 °C(lit.)

[ Molecular Formula ]:
CH₇ClN₄

[ Molecular Weight ]:
110.546

[ Flash Point ]:
111.9ºC

[ Exact Mass ]:
110.035927

[ PSA ]:
87.92000

[ LogP ]:
1.03640

[ Vapour Pressure ]:
0.0116mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ME8430000

CHEMICAL NAME :: Guanidine, amino-, hydrochloride

CAS REGISTRY NUMBER :: 1937-19-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C-H6-N4.Cl-H

MOLECULAR WEIGHT :: 110.57

WISWESSER LINE NOTATION :: ZMYZUM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2984 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 28,251,1926

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
ME8430000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.

J. Pathol. 235(4) , 581-92, (2015)

Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the stru...

Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation.

Phytochemistry 108 , 189-95, (2014)

Three aromatic glycosides (1-3), two sulfur and nitrogen-containing compound glucosides (4, 5), and one flavonoid glycoside (6) were isolated from the leaves of Ixora undulata. Their structures were e...

Vicenin 2 isolated from Artemisia capillaris exhibited potent anti-glycation properties.

Food Chem. Toxicol. 69 , 55-62, (2014)

Vicenin 2, isolated from a traditionally used medicinal plant Artemisia capillaris, is a 6,8-di-C-glucoside of apigenin which has been previously reported to possess a wide variety of pharmacological ...

Related Compounds

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