N-Methylguanosine

Names

[ Name ]:
N-Methylguanosine

[Synonym ]:
2-Methylguanosine
Guanosine, N-methyl-
N-Methylguanosine
Guanosine,N-methyl
9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methylamino-3H-purin-6-one
2-N-Methylguanosine
N(2)-Methylguanosine

Biological Activity

[Description]:

N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Ginell SL, et al. Conformation of N2-methylguanosine, a modified nucleoside of tRNA. Biochem Biophys Res Commun. 1978 Oct 30;84(4):886-94.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
709.5ºC at 760mmHg

[ Melting Point ]:
233 °C (decomp)(Solv: water (7732-18-5))

[ Molecular Formula ]:
C₁₁H₁₅N₅O₅

[ Molecular Weight ]:
297.267

[ Flash Point ]:
382.9ºC

[ Exact Mass ]:
297.107330

[ PSA ]:
145.52000

[ LogP ]:
-3.09

[ Vapour Pressure ]:
3.99E-21mmHg at 25°C

[ Index of Refraction ]:
1.850

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Articles

Exometabolom analysis of breast cancer cell lines: Metabolic signature.

Sci. Rep. 5 , 13374, (2015)

Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of differen...

Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.

J. Chromatogr. A. 1365 , 12-8, (2014)

A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer b...

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.

Proc. Natl. Acad. Sci. U. S. A. 106 , 3484-3489, (2009)

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to ca...

Related Compounds

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