2-di-1-asp

Names

[ Name ]:
2-di-1-asp

[Synonym ]:
D-308
2-{2-[4-(dimethylamino)phenyl]ethenyl}-1-methylpyridinium iodide
2m2Pm
2-(4-(Dimethylamino)styryl)-N-methylpyridinium
MFCD00011980
o-DPD
2-<4-(dimethylamino)styryl>-1-ethylpyridinium iodide
2-(4-(dimethylamino)styryl)-1-methylpyridinium
(E)-2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide
2-(4-DIMETHYLAMINOSTYRYL)-1-METHYLPYRIDINIUM IODIDE
2-DI-1-ASP
EINECS 218-460-8
1-METHYL-2-P-DIMETHYLAMINO-STYRYL-PYRIDINIUM-IODIDE

Biological Activity

[Description]:

2-Di-1-ASP (Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

2-Di-1-ASP (Compound 18a) displays significant fluorescence enhancements in the presence of G-quadruplex (G4) structures (up to 300-fold), and good selectivity with respect to double-stranded DNA. 2-Di-1-ASP shows fluorimetric selectivity for parallel G4-DNA forms (c-kit2, c-kit87up, c-myc)[1].

[References]

[1]. Xie X, et al. Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries. Beilstein J Org Chem. 2019 Aug 6;15:1872-1889.

Chemical & Physical Properties

[ Density]:
1.091g/cm3

[ Boiling Point ]:
397.8℃at 760 mmHg

[ Melting Point ]:
280ºC (dec.)(lit.)

[ Molecular Formula ]:
C₁₆H₁₉IN₂

[ Molecular Weight ]:
366.24000

[ Flash Point ]:
179.3℃

[ Exact Mass ]:
366.05900

[ PSA ]:
7.12000

[ Vapour Pressure ]:
1.55E-06mmHg at 25°C

[ Index of Refraction ]:
1.668

[ Water Solubility ]:
DMSO: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008)

The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-...

Distribution pattern of viable mitochondria in bovine lens epithelial cells.

Dev. Ophthalmol. 26 , 90-6, (1994)

Live-cell imaging of the cytoskeleton and mitochondrial-cytoskeletal interactions in budding yeast.

Methods Mol. Biol. 586 , 41-68, (2009)

This chapter describes labeling methods and optical approaches for live-cell imaging of the cytoskeleton and of a specific organelle-cytoskeleton interaction in budding yeast.

Related Compounds

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