NG,NG-Dimethylarginine Dihydrochloride

Names

[ CAS No. ]:
220805-22-1

[ Name ]:
NG,NG-Dimethylarginine Dihydrochloride

[Synonym ]:
asym-Dimethylarginine ADMA
NG,NG-Dimethylarginine dihydrochloride
MFCD00270857
(Z)-N-[Amino(dimethylamino)methylene]-L-ornithine dihydrochloride
L-Ornithine, N-[amino(dimethylamino)methylene]-, (Z)-, hydrochloride (1:2)
NG,NG-DimethylarginineDihydrochloride
(2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid,dihydrochloride

Biological Activity

[Description]:

Asymmetric dimethylarginine dihydrochloride is an endogenous NO synthase inhibitor that reduces NO production, which contributes to endothelial dysfunction and cardiovascular disease[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[References]

[1]. Latika Sibal, et al. The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr Cardiol Rev. 2010 May;6(2):82-90.

Chemical & Physical Properties

[ Boiling Point ]:
427.5ºC at 760 mmHg

[ Melting Point ]:
202-204OºC

[ Molecular Formula ]:
C₈H₂₀Cl₂N₄O₂

[ Molecular Weight ]:
275.18

[ Flash Point ]:
212.4ºC

[ Exact Mass ]:
274.096344

[ PSA ]:
102.44000

[ LogP ]:
2.05940

[ Vapour Pressure ]:
1.66E-08mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.

J. Biol. Chem. 290 , 16723-43, (2015)

Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splic...

PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.

Nat. Commun. 6 , 6428, (2015)

The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two splic...

Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.

Mol. Med. Report. 12 , 2253-62, (2015)

A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interactio...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.