4-Hydroxyindole

Names

[ Name ]:
4-Hydroxyindole

[Synonym ]:
1H-Indol-4-ol
4-Hydroxylndole
1H-Indol-7-ol
EINECS 219-177-2
indol-4-ol
7-Hydroxyindol
7-HYDROXYLINDOLE
4-hydroxy-indole
INDOL-7-OL
7-HYDROXY-1H-INDOLE
7-monohydroxyindole
7-hydroxyindole
1H-INDOLE-4-OL
4-Hydroxxyindole
7-Indolol
MFCD00005667
4-Hydroxyindole
4-hydroxy-1H-indole
4-INDOLOL

Biological Activity

[Description]:

4-Hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. 4-Hydroxyindole is an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Nenad Manevski, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010 Mar;38(3):386-95.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
343.2±15.0 °C at 760 mmHg

[ Melting Point ]:
97-99 °C(lit.)

[ Molecular Formula ]:
C₈H₇NO

[ Molecular Weight ]:
133.147

[ Flash Point ]:
161.4±20.4 °C

[ Exact Mass ]:
133.052765

[ PSA ]:
36.02000

[ LogP ]:
1.41

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.739

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 68-76, (2014)

• Optimization of a suitable extraction protocol for alkylindoles and their metabolites from biological fluids. • Detection of alkylindoles and their metabolites by means of the GC/MS method adopted b...

Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market.

Forensic Sci. Int. 243 , 117-25, (2014)

An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids a...

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

Drug Metab. Dispos. 38(3) , 386-95, (2010)

We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the 19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. The glucuronidation o...

Related Compounds

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